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Effect of Combined Treatment of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-Reperfusion Injury in Patients Undergoing Partial Nephrectomy: Pilot Study

DC Field Value Language
dc.contributor.author김지영-
dc.contributor.author이혜선-
dc.contributor.author최영득-
dc.contributor.author이혜선-
dc.contributor.author최영득-
dc.date.accessioned2019-02-14T01:55:46Z-
dc.date.available2019-02-14T01:55:46Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167298-
dc.description.abstractWe evaluated postoperative renal function in patients with/without combined therapy of ketorolac and remote ischemic preconditioning during partial nephrectomy. Sixteen patients were randomly allocated to either the ketorolac combined with RIPC group (KI, n = 8) or control group (n = 8). The KI group received both remote ischemic preconditioning before surgery and intravenous ketorolac of 1 mg/kg before renal artery clamping. Renal parameters were measured before induction, after anesthesia induction, and 2, 12, 24, 48, and 72 h after renal artery declamping. Acute kidney injury was assessed by Acute Kidney Injury Network criteria. The estimated glomerular filtration rate decreased in both groups, but then increased significantly at 48 h and 72 h after declamping only in the KI group compared to 24 h (p = 0.001 and p = 0.016). Additionally, it was higher at 48 h and 72 h after declamping in the KI group compared to the control group (p = 0.025 and p = 0.044). The incidence of acute kidney injury was significantly reduced in the KI group (13%) compared to the control group (83%) (p = 0.026). FENa was markedly increased at 2 h after declamping, and recovered in both groups, but it was more significant at 12 h after declamping in the KI group (p = 0.022). Urinary N-acetyl-1-β-D-glucosoaminidase and serum neutrophil gelatinase-associated lipocalin were similar (p = 0.291 and p = 0.818). There is a possibility that combined therapy of ketorolac and remote ischemic preconditioning prior to ischemia may alleviate renal dysfunction and reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffect of Combined Treatment of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-Reperfusion Injury in Patients Undergoing Partial Nephrectomy: Pilot Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorHae Keum Kil-
dc.contributor.googleauthorJi Young Kim-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorTae Kwang Kim-
dc.contributor.googleauthorJi Eun Kim-
dc.identifier.doi10.3390/jcm7120470-
dc.contributor.localIdA00977-
dc.contributor.localIdA03312-
dc.contributor.localIdA03312-
dc.contributor.localIdA04111-
dc.contributor.localIdA04111-
dc.contributor.localIdA03312-
dc.contributor.localIdA03312-
dc.contributor.localIdA04111-
dc.contributor.localIdA04111-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid30477089-
dc.subject.keywordacute kidney injury-
dc.subject.keywordischemic preconditioning-
dc.subject.keywordketorolac-
dc.contributor.alternativeNameKim, Ji Young-
dc.contributor.affiliatedAuthor김지영-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor최영득-
dc.contributor.affiliatedAuthor최영득-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor최영득-
dc.contributor.affiliatedAuthor최영득-
dc.citation.volume7-
dc.citation.number12-
dc.citation.startPageE470-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.7(12) : E470, 2018-
dc.identifier.rimsid61500-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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