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Global analysis of gene expression profiles in the submandibular salivary gland of klotho knockout mice

Authors
 Sung-Min Kwon  ;  Soo-A Kim  ;  Jung-Hoon Yoon  ;  Jong-In Yook  ;  Sang-Gun Ahn 
Citation
 JOURNAL OF CELLULAR PHYSIOLOGY, Vol.233(4) : 3282-3294, 2018 
Journal Title
 JOURNAL OF CELLULAR PHYSIOLOGY 
ISSN
 0021-9541 
Issue Date
2018
Keywords
aging ; gene profiling ; klotho ; salivary gland
Abstract
Salivary dysfunction commonly occurs in many older adults and is considered a physiological phenomenon. However, the genetic changes in salivary glands during aging have not been characterized. The present study analyzed the gene expression profile in salivary glands from accelerated aging klotho deficient mice (klotho-/-, 4 weeks old). Microarray analysis showed that 195 genes were differentially expressed (z-score > 2 in two independent arrays) in klotho null mice compared to wild-type mice. Importantly, alpha2-Na+ /K+ -ATPase (Atp1a2), Ca2+ -ATPase (Atp2a1), epidermal growth factor (EGF), and nerve growth factor (NGF), which have been suggested to be regulators of submandibular salivary gland function, were significantly decreased. When a network was constructed from the differentially expressed genes, proliferator-activated receptor-γ (PPAR γ), which regulates energy homeostasis and insulin sensitivity, was located at the core of the network. In addition, the expression of genes proposed to regulate various PPAR γ-related cellular pathways, such as Klk1b26, Egfbp2, Cox8b, Gpx3, Fabp3, EGF, and NGFβ, was altered in the submandibular salivary glands of klotho-/- mice. Our results may provide clues for the identification of novel genes involved in salivary gland dysfunction. Further characterization of these differentially expressed genes will be useful in elucidating the genetic basis of aging-related changes in the submandibular salivary gland.
Files in This Item:
T201805437.pdf Download
DOI
10.1002/jcp.26172
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167270
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