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Bioactive Compounds for the Treatment of Renal Disease

Authors
 Kang Su Cho  ;  In Kap Ko  ;  James J. Yoo 
Citation
 Yonsei Medical Journal, Vol.59(9) : 1015-1025, 2018 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2018
MeSH
Acute Kidney Injury/pathology ; Acute Kidney Injury/therapy* ; Animals ; Cell Transplantation ; Cell- and Tissue-Based Therapy* ; Cytokines ; Humans ; Intercellular Signaling Peptides and Proteins ; Kidney Diseases/pathology ; Kidney Diseases/therapy* ; Regenerative Medicine/methods* ; Stem Cell Transplantation ; Stem Cells ; Tissue Engineering*/methods ; Treatment Outcome
Keywords
Acute kidney injury ; chronic ; kidney failure ; regenerative medicine ; tissue engineering
Abstract
Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventions have shown promise in the pre-clinical and clinical settings. More recently, therapeutic cell-secreting secretomes have emerged as a potential alternative to cell-based approaches. This approach involves the use of renotropic factors, such as growth factors and cytokines, that are produced by cells and these factors have shown effectiveness in facilitating kidney function recovery. This review focuses on the renotropic functions of bioactive compounds that provide protective and regenerative effects for kidney tissue repair, based on the available data in the literature.
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T201805411.pdf Download
DOI
10.3349/ymj.2018.59.9.1015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167246
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