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Amatoxin 중독 환자에서 Silymarin, Penicillin, N-acetylcysteine의 효과 비교: 체계적 고찰
DC Field | Value | Language |
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dc.contributor.author | 고동률 | - |
dc.contributor.author | 공태영 | - |
dc.contributor.author | 유제성 | - |
dc.contributor.author | 정성필 | - |
dc.contributor.author | 좌민홍 | - |
dc.contributor.author | 최민우 | - |
dc.date.accessioned | 2019-02-12T16:50:58Z | - |
dc.date.available | 2019-02-12T16:50:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1738-1320 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167184 | - |
dc.description.abstract | Purpose: This study was conducted to evaluate the clinical efficacy of pharmacologic treatment of amatoxin poisoning patients. Methods: Literature was accessed through PubMed, EMBASE, Cochrane library, KoreaMed, KISS and KMBASE. Studies relevant to human use of pharmacologic therapy including silymarin, penicillin and N-acetylcysteine (NAC) for amanita poisoning were included. Case reports, letters, editorials and papers with insufficient information were excluded. Comparison of clinical outcomes (especially mortality and liver transplantation rate) in each study was analyzed. Results: The final analysis included 13 retrospective studies. None of these studies showed direct comparisons of individual agents. Among 12 studies comparing silymarin vs penicillin, eight showed clinical superiority of silymarin. Among eight studies comparing silymarin with NAC, six showed clinical superiority of silymarin. Among seven studies of NAC vs penicillin, five showed clinical superiority of NAC. Conclusion: This systematic review suggested that clinical superiority of various pharmacological agents used to treat amatoxin poisoning is debatable. Nevertheless, the available evidence suggests it is reasonable to consider combinations of multiple agents for patients with amanita poisoning. Further studies are required to establish a treatment regimen for amanita poisoning. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 대한임상독성학회 | - |
dc.relation.isPartOf | Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Amatoxin 중독 환자에서 Silymarin, Penicillin, N-acetylcysteine의 효과 비교: 체계적 고찰 | - |
dc.title.alternative | Comparison of Silymarin, Penicillin, N-acetylcysteine in Patient with Amatoxin Poisoning: A Systematic Review | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Emergency Medicine (응급의학교실) | - |
dc.contributor.googleauthor | 최민우 | - |
dc.contributor.googleauthor | 고동률 | - |
dc.contributor.googleauthor | 공태영 | - |
dc.contributor.googleauthor | 좌민홍 | - |
dc.contributor.googleauthor | 유제성 | - |
dc.contributor.googleauthor | 정성필 | - |
dc.identifier.doi | 10.22537/jksct.16.1.33 | - |
dc.contributor.localId | A00113 | - |
dc.contributor.localId | A00162 | - |
dc.contributor.localId | A02507 | - |
dc.contributor.localId | A03625 | - |
dc.contributor.localId | A03947 | - |
dc.contributor.localId | A05688 | - |
dc.relation.journalcode | J01862 | - |
dc.subject.keyword | Amatoxin | - |
dc.subject.keyword | Poisoning | - |
dc.subject.keyword | Silymarin | - |
dc.subject.keyword | Silibinin | - |
dc.subject.keyword | Penicillin | - |
dc.subject.keyword | Acetylcysteine | - |
dc.contributor.alternativeName | Ko, Dong Ryul | - |
dc.contributor.affiliatedAuthor | 고동률 | - |
dc.contributor.affiliatedAuthor | 공태영 | - |
dc.contributor.affiliatedAuthor | 유제성 | - |
dc.contributor.affiliatedAuthor | 정성필 | - |
dc.contributor.affiliatedAuthor | 좌민홍 | - |
dc.contributor.affiliatedAuthor | 최민우 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 41 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지), Vol.16(1) : 33-41, 2018 | - |
dc.identifier.rimsid | 58160 | - |
dc.type.rims | ART | - |
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