0 207

Cited 0 times in

Catalyst-Free Aromatic Radiofluorination via Oxidized Iodoarene Precursors

Authors
 Young-Do Kwon  ;  Jeongmin Son  ;  Joong-Hyun Chun 
Citation
 ORGANIC LETTERS, Vol.20(24) : 7902-7906, 2018 
Journal Title
 ORGANIC LETTERS 
ISSN
 1523-7060 
Issue Date
2018
Abstract
Oxidized iodoarenes (OIAs), prepared via mCPBA-mediated oxidation, have been demonstrated as versatile precursors for the synthesis of [18F]fluoroarenes in the absence of catalysts. OIAs have been identified as intermediates in single-pot syntheses of iodonium salts and ylides but have never been recognized as radiofluorination precursors. Here, the isolated OIAs were used without any catalysts to produce functionalized [18F]fluoroarenes, regardless of the electronic nature of the arenes. This method was also applied to the production of radiolabeling synthons for use as aromatic 18F-labeled building blocks.
Full Text
https://pubs.acs.org/doi/10.1021/acs.orglett.8b03450
DOI
10.1021/acs.orglett.8b03450
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Chun, Joong-Hyun(전중현) ORCID logo https://orcid.org/0000-0002-9665-7829
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167131
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links