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Retinal fluid changes and therapeutic effects in symptomatic circumscribed choroidal hemangioma patients: a long-term follow up study

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dc.contributor.author김민-
dc.contributor.author이성철-
dc.contributor.author이승규-
dc.contributor.author이준원-
dc.date.accessioned2019-02-12T16:41:48Z-
dc.date.available2019-02-12T16:41:48Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167091-
dc.description.abstractBACKGROUND: Changes in retinal fluid patterns associated with circumscribed choroidal hemangioma (CCH) have not been investigated yet. A long-term follow-up study was performed to evaluate the changes of retinal fluid patterns and treatment responses. METHODS: We retrospectively reviewed medical records of all CCH patients diagnosed between November 2005 and March 2017. Enrolled patients had visual symptoms, were treatment-naïve, and had been followed-up for more than 2 years. Best corrected visual acuities (BCVA) and the presence, severity, and pattern change of the subretinal fluid (SRF) and intraretinal fluid (IRF) in the macula on optical coherence tomography (OCT) were analyzed at initial presentation and follow-up visits. RESULTS: Twenty-six patients were enrolled. All patients received one or more of the following treatments: PDT, TTT, and intravitreal bevacizumab (Avastin) injection (IVB). Primary therapy consisted of PDT in 9 patients (34.6%), TTT in 7 patients (26.9%) and IVB in 10 patients (38.5%). At initial presentation, the SRF-only pattern was mostly observed. Despite treatment, IRF occurred over time; eventually, advanced cystoid macular oedema (CME) developed. In terms of retinal fluid reduction, PDT was most efficacious (9/9, 100%), and TTT and IVB showed moderate efficacy (TTT: 4/7, 57.1%; IVB: 5/10, 50%) as a primary therapy. After advanced CME developed, IVB and TTT showed no or minimal effect (TTT: 0/1, 0%; IVB: 0/19, 0%), and PDT was the only effective therapy (6/10, 60%). CONCLUSION: The pattern of retinal fluid accompanied by CCH evolved from an SRF-only pattern initially to an advanced CME pattern. The effectiveness of treatments decreased over time, and advanced CME generally showed resistance to treatments. PDT would be the most recommended treatment.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC Ophthalmology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRetinal fluid changes and therapeutic effects in symptomatic circumscribed choroidal hemangioma patients: a long-term follow up study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorJunwon Lee-
dc.contributor.googleauthorChristopher Seungkyu Lee-
dc.contributor.googleauthorMin Kim-
dc.contributor.googleauthorSung Chul Lee-
dc.identifier.doi10.1186/s12886-018-0993-x-
dc.contributor.localIdA00455-
dc.contributor.localIdA02873-
dc.contributor.localIdA02873-
dc.contributor.localIdA02913-
dc.contributor.localIdA02913-
dc.contributor.localIdA03179-
dc.contributor.localIdA03179-
dc.relation.journalcodeJ00370-
dc.identifier.eissn1471-2415-
dc.identifier.pmid30545324-
dc.subject.keywordChoroidal hemangioma-
dc.subject.keywordCystoid macular oedema-
dc.subject.keywordPhotodynamic therapy-
dc.subject.keywordRetinal fluid pattern-
dc.contributor.alternativeNameKim, Min-
dc.contributor.affiliatedAuthor김민-
dc.contributor.affiliatedAuthor이성철-
dc.contributor.affiliatedAuthor이성철-
dc.contributor.affiliatedAuthor이승규-
dc.contributor.affiliatedAuthor이승규-
dc.contributor.affiliatedAuthor이준원-
dc.contributor.affiliatedAuthor이준원-
dc.citation.volume18-
dc.citation.number1-
dc.citation.startPage321-
dc.identifier.bibliographicCitationBMC Ophthalmology, Vol.18(1) : 321, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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