Cited 24 times in
Long-term Outcome of Resective Epilepsy Surgery in Patients With Lennox-Gastaut Syndrome
DC Field | Value | Language |
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dc.contributor.author | 이준수 | - |
dc.contributor.author | 엄소용 | - |
dc.contributor.author | 강훈철 | - |
dc.contributor.author | 김흥동 | - |
dc.contributor.author | 이영목 | - |
dc.contributor.author | 김동석 | - |
dc.date.accessioned | 2019-01-24T16:40:48Z | - |
dc.date.available | 2019-01-24T16:40:48Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0031-4005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166986 | - |
dc.description.abstract | OBJECTIVE: We aimed to evaluate the long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome (LGS). METHODS: We reviewed the case reports of 90 patients with LGS who had undergone resective surgery between 2003 and 2014 at the Severance Children's Hospital and managed them for a minimum period of 2 years. RESULTS: At the time of surgery, the patients were between 3.0 and 23.5 years old (mean ± SD: 9.3 ± 4.4). The time from seizure onset to surgery ranged from 0.7 to 20.1 years (7.2 ± 4.3). On postoperative follow-up for an average period of 6.1 ± 2.2 years (range: 2.1-11.4 years), 45 patients (50.0%) had no seizures, and 15 (16.7%) reported infrequent seizures. Seizure-free outcomes were achieved in 15 of the 21 (71.4%) hemispherectomies, 23 of the 51 (45.1%) multilobar resections, and 7 of the 18 (38.9%) single lobar resections. On high-resolution MRIs, 20 patients (22.2%) had negative findings, 8 of whom (40.0%) became seizure-free after resective surgery. Malformation of cortical development was the most common pathologic finding and was noted in 57 patients (63.3%). Seizure-free patients achieved better adaptive behavior and social competence than did patients with persistent seizures at the second (2-3 years after surgery) and third (4-6 years after surgery) follow-ups, as indicated by social quotients (P < .05). CONCLUSIONS: Resective surgery is a viable option in some patients to treat seizures that are associated with LGS, with a high probability of seizure control and better adaptive function. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Academy of Pediatrics | - |
dc.relation.isPartOf | PEDIATRICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Long-term Outcome of Resective Epilepsy Surgery in Patients With Lennox-Gastaut Syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Joon Won Kang | - |
dc.contributor.googleauthor | Soyong Eom | - |
dc.contributor.googleauthor | William Hong | - |
dc.contributor.googleauthor | Hye Eun Kwon | - |
dc.contributor.googleauthor | Soyoung Park | - |
dc.contributor.googleauthor | Ara Ko | - |
dc.contributor.googleauthor | Hoon-Chul Kang | - |
dc.contributor.googleauthor | Joon Soo Lee | - |
dc.contributor.googleauthor | Young-Mock Lee | - |
dc.contributor.googleauthor | Dong Seok Kim | - |
dc.contributor.googleauthor | Heung Dong Kim | - |
dc.identifier.doi | 10.1542/peds.2018-0449 | - |
dc.contributor.localId | A03177 | - |
dc.contributor.localId | A02334 | - |
dc.contributor.localId | A00102 | - |
dc.contributor.localId | A01208 | - |
dc.contributor.localId | A02955 | - |
dc.contributor.localId | A00402 | - |
dc.relation.journalcode | J02496 | - |
dc.identifier.eissn | 1098-4275 | - |
dc.identifier.pmid | 30194277 | - |
dc.identifier.url | http://pediatrics.aappublications.org/content/142/4/e20180449.long | - |
dc.contributor.alternativeName | Lee, Joon Soo | - |
dc.contributor.affiliatedAuthor | 이준수 | - |
dc.contributor.affiliatedAuthor | 엄소용 | - |
dc.contributor.affiliatedAuthor | 강훈철 | - |
dc.contributor.affiliatedAuthor | 김흥동 | - |
dc.contributor.affiliatedAuthor | 이영목 | - |
dc.contributor.affiliatedAuthor | 김동석 | - |
dc.citation.volume | 142 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e20180449 | - |
dc.identifier.bibliographicCitation | PEDIATRICS, Vol.142(4) : e20180449, 2018 | - |
dc.identifier.rimsid | 58374 | - |
dc.type.rims | ART | - |
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