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헌혈이 헌혈자의 혈유변학적 지표에 미치는 영향

Other Titles
 Effect of Blood Donation on the Donor’s Hemorheological Properties 
Authors
 이병권 
Citation
 Korean Journal of Blood Transfusion (대한수혈학회지), Vol.29 : 229-239, 2018 
Journal Title
 Korean Journal of Blood Transfusion (대한수혈학회지) 
ISSN
 1226-9336 
Issue Date
2018
Keywords
Blood viscosity ; Erythrocyte aggregation ; Hematocrit, ferritin ; Blood donors
Abstract
The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.
Files in This Item:
T201805366.pdf Download
DOI
10.17945/kjbt.2018.29.3.229
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166893
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