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Quality of Anticoagulation and Treatment Satisfaction in Patients with Non-Valvular Atrial Fibrillation Treated with Vitamin K Antagonist: Result from the KORean Atrial Fibrillation Investigation II

 Seil Oh  ;  June-Soo Kim  ;  Yong-Seog Oh  ;  Dong-Gu Shin  ;  Hui-Nam Pak  ;  Gyo-Seung Hwang  ;  Kee-Joon Choi  ;  Jin-Bae Kim  ;  Man-Young Lee  ;  Hyung-Wook Park  ;  Dae-Kyeong Kim  ;  Eun-Sun Jin  ;  Jaeseok Park  ;  Il-Young Oh  ;  Dae-Hee Shin  ;  Hyoung-Seob Park  ;  Jun Hyung Kim  ;  Nam-Ho Kim  ;  Min-Soo Ahn  ;  Bo-Jeong Seo  ;  Young-Joo Kim  ;  Seongsik Kang  ;  Juneyoung Lee  ;  Young-Hoon Kim 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.33(49) : e323, 2018 
Journal Title
Issue Date
Anticoagulation ; Atrial Fibrillation ; INR Control ; Satisfaction ; Vitamin K Antagonist
Background: Vitamin K antagonist (VKA) to prevent thromboembolism in non-valvular atrial fibrillation (NVAF) patients has limitations such as drug interaction. This study investigated the clinical characteristics of Korean patients treated with VKA for stroke prevention and assessed quality of VKA therapy and treatment satisfaction. Methods: We conducted a multicenter, prospective, non-interventional study. Patients with CHADS2 ≥ 1 and treated with VKA (started within the last 3 months) were enrolled from April 2013 to March 2014. Demographic and clinical features including risk factors of stroke and VKA treatment information was collected at baseline. Treatment patterns and international normalized ratio (INR) level were evaluated during follow-up. Time in therapeutic range (TTR) > 60% indicated well-controlled INR. Treatment satisfaction on the VKA use was measured by Treatment Satisfaction Questionnaire for Medication (TSQM) after 3 months of follow-up. Results: A total of 877 patients (age, 67; male, 60%) were enrolled and followed up for one year. More than half of patients (56%) had CHADS2 ≥ 2 and 83.6% had CHA2DS2-VASc ≥ 2. A total of 852 patients had one or more INR measurement during their follow-up period. Among those patients, 25.5% discontinued VKA treatment during follow-up. Of all patients, 626 patients (73%) had poor-controlled INR (TTR < 60%) measure. Patients' treatment satisfaction measured with TSQM was 55.6 in global satisfaction domain. Conclusion: INR was poorly controlled in Korean NVAF patients treated with VKA. VKA users also showed low treatment satisfaction.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Pak, Hui Nam(박희남) ORCID logo https://orcid.org/0000-0002-3256-3620
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