25 36

Cited 0 times in

Antithrombotic treatments in patients with acute ischemic stroke and non-valvular atrial fibrillation before introduction of non-vitamin K antagonist oral anticoagulants into practice in Korea

Authors
 Hee-Joon Bae  ;  Ji Hoe Heo  ;  Keun-Hwa Jung  ;  Yong-Seok Lee  ;  Keun-Sik Hong  ;  Woo-Keun Seo  ;  Jaseong Koo  ;  Jae-Kwan Cha  ;  Mi Ji Lee  ;  Bo-Jeong SeoI  ;  Joo Kim  ;  Seongsik Kang  ;  Jinmi Seok  ;  Juneyoung Lee  ;  Chin-Sang Chung 
Citation
 PLoS One, Vol.13(11) : e202803, 2018 
Journal Title
 PLoS One 
Issue Date
2018
Abstract
BACKGROUND: This study aimed to describe patterns of long-term antithrombotic use in acute ischemic stroke (AIS) patients with non-valvular atrial fibrillation (NVAF) in Korea and their impacts on clinical events before introduction of non-vitamin K antagonist oral anticoagulants (NOAC) into practice in 2015. METHODS: Patients with NVAF who were admitted due to the AIS and discharged no later than 2008 were enrolled retrospectively. Data were collected at 11 time points during the first 3 years of follow-up. The primary outcome event was a composite of stroke recurrence, major bleeding, and death. Vitamin K antagonist (VKA) users were categorized into a well-controlled INR group and a poorly-controlled INR group (modified TTR ≥47.0% vs <47.0%). RESULTS: Of 1,350 patients enrolled in this study, 95% were on antithrombotic medications at discharge. The rate of VKA usage decreased over time (77% and 40% at discharge and 3 years, respectively). The cumulative event rates of the primary outcome differed by treatment patterns. Among the 10 most frequent treatment types, the highest outcome rate was observed in patients who started with VKA-only therapy but discontinued VKAs during follow-up without restarting (70.2%); this was followed by those starting with antiplatelet-only therapy and stopping it without restart (66.7%). Among VKA users, the 3-year cumulative primary outcome rates were higher in the poorly-controlled INR group than the well-controlled INR group (24.5% vs 15.7%; p = 0.015). CONCLUSION: Our study revealed that, in pre-NOAC era, there was a wide spectrum of long-term antithrombotic use. The incidence of the composite outcome also varied by patterns of antithrombotic use.
Files in This Item:
T201804712.pdf.pdf Download
DOI
10.1371/journal.pone.0202803
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
허지회(Heo, Ji Hoe) ORCID logo https://orcid.org/0000-0001-9898-3321
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166800
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse