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Prevalence, Incidence, Comorbidity, and Mortality Rates of Ossification of Posterior Longitudinal Ligament in the Cervical Spine: A Nested Case-Control Cohort Study

Authors
 Bong Ju Moon  ;  Sun Kyu Choi  ;  Dong Ah Shin  ;  Seong Yi  ;  Keung Nyun Kim  ;  Do Heum Yoon  ;  Yoon Ha 
Citation
 World Neurosurgery, Vol.117 : e323-e328, 2018 
Journal Title
 World Neurosurgery 
ISSN
 1878-8750 
Issue Date
2018
MeSH
Age Distribution ; Aged ; Case-Control Studies ; Cervical Vertebrae/surgery* ; Female ; Humans ; Incidence ; Male ; Ossification of Posterior Longitudinal Ligament/mortality* ; Ossification of Posterior Longitudinal Ligament/surgery ; Prevalence ; Republic of Korea/epidemiology ; Sex Distribution
Keywords
Cervical ; Diabetes ; OPLL ; Prevalence ; Surgery
Abstract
OBJECTIVE: To evaluate prevalence, incidence, morbidity, and mortality rates of cervical ossification of posterior longitudinal ligament (OPLL) using data from a 12-year national cohort of 1,025,340 Korean people. METHODS: A nested case-control cohort study was performed from 2002 to 2013 using the insurance claims database provided by the National Health Insurance Service. We examined prevalence and incidence of cervical OPLL. Age- and sex-matched control subjects were randomly extracted, with 10 times the number of OPLL cases. Differences in sex, comorbidity, and relative survival rate compared with control subjects were assessed. RESULTS: Cumulative prevalence was 20,960 per 1,025,340 people for 12 years. Annual incidence was approximately 199-371 per 1 million people. Overall crude mortality rate was 7.64%. Relative survival rate of OPLL cases was not significantly different from control cases. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases (P < 0.001). Additionally, between dead and surviving patients among OPLL cases, all comorbidities correlated more significantly with death (P < 0.001). Furthermore, between surgery and nonsurgery cases of OPLL, diabetes, hypertension, and renal disease (P < 0.05) were significantly associated with surgery. CONCLUSIONS: Annual incidence of OPLL was 199-371 per 1,025,340 people for 10 years. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases. Especially, diabetes, hypertension, and renal disease were associated with patients with OPLL who underwent surgery.
Full Text
https://www.sciencedirect.com/science/article/pii/S1878875018312385
DOI
10.1016/j.wneu.2018.06.023
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
김긍년(Kim, Keung Nyun)
신동아(Shin, Dong Ah) ORCID logo https://orcid.org/0000-0002-5225-4083
윤도흠(Yoon, Do Heum) ORCID logo https://orcid.org/0000-0003-1452-5724
이성(Yi, Seong)
하윤(Ha, Yoon)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166746
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