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Relationship Between Anemia and the Risk of Sudden Cardiac Arrest - A Nationwide Cohort Study in South Korea

Authors
 In-Jung Kim  ;  Pil-Sung Yang  ;  Tae-Hoon Kim  ;  Jae-Sun Uhm  ;  Hui-Nam Pak  ;  Moon-Hyoung Lee  ;  Jung-Hoon Sung  ;  Boyoung Joung 
Citation
 CIRCULATION JOURNAL, Vol.82(12) : 2962-2969, 2018 
Journal Title
 CIRCULATION JOURNAL 
ISSN
 1346-9843 
Issue Date
2018
Keywords
Anemia ; General population ; Sudden cardiac arrest
Abstract
BACKGROUND: The relationship between anemia and sudden cardiac arrest (SCA) is unclear in the general population, so we assessed it in a nationwide cohort.Methods and Results: We studied 494,948 subjects (mean age, 47.8 years; 245,333 men [49.6%]) with national health check-up data from the Korean National Health Insurance Database Cohort. During a mean follow-up period of 5.4 years, SCA occurred in 616 participants (396 men, 220 women). The incidence rates of SCA increased across the 4 anemia groups in both men (0.3, 1.5, 5.3, and 4.5 per 1,000 person-years) and women (0.2, 0.5, 0.5, and 1.2 per 1,000 person-years). The SCA risk per 1-unit decrease in hemoglobin (Hb) increased by 21% and 24%, respectively, in multivariable models adjusted for cardiovascular factors, in men (95% confidence interval [CI], 13-29%; P<0.001) and women (95% CI, 13-37%; P<0.001). A negative correlation between QTc interval and Hb level was observed in men, and a trend was observed in women. CONCLUSIONS: Anemia was associated with an increased risk of SCA even after accounting for concomitant conditions in a South Korean nationwide cohort. The correlation between anemia and SCA might be explained by an increase in arrhythmic risks, such as QTc prolongation.
Files in This Item:
T201804556.pdf.pdf Download
DOI
10.1253/circj.CJ-18-0046
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-4200-3456
Pak, Hui Nam(박희남) ORCID logo https://orcid.org/0000-0002-3256-3620
Uhm, Jae Sun(엄재선) ORCID logo https://orcid.org/0000-0002-1611-8172
Lee, Moon Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166734
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