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Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats

Authors
 Jun Won PARK  ;  Ki Taek NAM  ;  Jae Hoon SHIN  ;  Il Yong KIM  ;  Kyung Mi CHOI  ;  Kyung-Jin ROH  ;  Seung Hyun OH  ;  Young-Min YUN  ;  Jun-Gyo SUH  ;  Yang-Seok OH  ;  Yeo Sung YOON  ;  Je Kyung SEONG 
Citation
 JOURNAL OF VETERINARY MEDICAL SCIENCE, Vol.80(10) : 1553-1557, 2018 
Journal Title
 JOURNAL OF VETERINARY MEDICAL SCIENCE 
ISSN
 0916-7250 
Issue Date
2018
Keywords
clusterin ; pancreatitis ; spontaneous hypertensive rat ; tubular complex
Abstract
Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.
Files in This Item:
T201804545.pdf.pdf Download
DOI
10.1292/jvms.18-0205
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166725
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