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Prevalence and risk factors of latent tuberculosis among Korean healthcare workers using whole-blood interferon-γ release assay

Authors
 Jeong Hwa Yeon  ;  Hye Seong  ;  Ho Hur  ;  Yoonseon Park  ;  Young Ah Kim  ;  Yoon Soo Park  ;  Chang Hoon Han  ;  Sun Min Lee  ;  Jeong Hun Seo  ;  Jung Gu Kang 
Citation
 SCIENTIFIC REPORTS, Vol.8(1) : 10113, 2018 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2018
Abstract
Because healthcare workers (HCWs) are at high risk for tuberculosis (TB) infection, it is essential to research the prevalence of latent TB infection (LTBI) and to implement health interventions including early treatment of LTBI and TB infection control measures. The purpose of the study was to determine the prevalence and risk factors for LTBI using interferon-γ release assay (IGRA) among HCWs in South Korea. The cross-sectional study was carried in the National Health Insurance Service Ilsan Hospital, which is a 740-bed general hospital, South Korea. HCWs who participated in this survey were required to complete a questionnaire and IGRA was performed. Of the 1,655 HCWs, 271 results were positive and the prevalence of LTBI was 16% (95% CI; 15-18%). In the multivariate analysis, age (OR; 2.201, 95% CI; 1.911-2.536, P < 0.001), male sex (OR; 1.523, 95% CI; 1.133-2.046, P = 0.005), contact active TB patients (OR; 1.461, 95% CI; 1.061-2.010, P = 0.02) and diabetes (OR; 2.837, 95% CI; 1.001-8.044, P = 0.05) were significant risk factors for LTBI. LTBI among HCWs in Korea, although prevalent, might not exceed the background level of the general population. Because contact with active TB patients has been identified as a risk factor for LTBI, more effective TB infection control measures are essential in healthcare facilities and congregate settings.
Files in This Item:
T999901495.pdf.pdf Download
DOI
10.1038/s41598-018-28430-w
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Seong, Hye(성혜) ORCID logo https://orcid.org/0000-0002-5633-7214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166561
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