351 548

Cited 0 times in

(The) role of oncolytic virus as an immunomodulator in the microenvironment of colon cancer mouse model

Other Titles
 대장암에서 항암 바이러스의 면역 미세환경 변화 기전에 대한 연구 
Authors
 김창우 
Department
 Dept. of Surgery (외과학교실) 
Degree
박사
Issue Date
2018
Description
의학과
Abstract
Immunotherapy for malignancy, which stimulates the patients’ own immune system to treat cancers with low toxicity, has been effective for MSI-high colorectal cancer. MSI-high diseases are less than 10% of overall colorectal cancer. Recent studies concentrate on synergizing the effect of immune checkpoint inhibitor by combination. Among them is an oncolytic virus. Tumor volumes after local injection of Oncolytic virus (OV) with anti-PD1 antibody decreased compared with OV alone or anti-PD1 antibody alone. Moreover, CD4+ T lymphocyte infiltration markedly increased as well as CD8+T lymphocyte infiltration when combination of OV and anti-PD1 antibody applied. OV can immunomodulate as well as replicate and kill the cancer cell. The combination of OV and anti-PD1 antibody can benefit for patients with tumors that are resistant to other therapies.
Files in This Item:
T014958.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 3. Dissertation
Yonsei Authors
Kim, Chang Woo(김창우)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166441
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links