소아 인플루엔자 폐렴에서 Mycoplasma Pneumoniae 감염의 임상적 의의

Abstract

Purpose: Mycoplasma pneumoniae (MP) is one of the most common causes of childhood community-aquired pneumonia and childhood influenza pneumonia patients also have been infected with it. But there are a few studies for its clinical significance in them domestically, so I have done this study to know that. Methods: I collected clinical informations of influenza pneumonia patients who had been diagnosed and admitted at the Department of Pediatrics , Yogin Severance Hospital from December 2013 to April 2017. MP infection was detected with enzyme immunoassay. They were divided into group A (who had MP infection) and group B (who had not it). Their epidemiological and clinical characteristics have been investigated and compared. Results: There were 25 cases for group A and 35 cases for group B. Comparing group B, the most prevalent month and season of group A were December ( P =0.008) and 2016-2017 season ( P =0.010). Ages of group A and group B were 74.7±47.3 months old and 57.2±49.8 months old, respectively. Proportions of the patients being 3 years old and over were 80% for group A and 50.0% for group B ( P =0.016). Male to female ratios were 1:1.5 for group A and 1:1.2 for group B. Their clinical manifestations regarding to antigenic type composition, durations of fever, and frequency of fever, cough, sputum, rhinorrhea, abdominal pain, vomiting, diarrhea, nausea, lethargy did not showed any significant difference between two groups. Admission durations of the two groups were comparable with each other (3.8±1.2 days for group A and 3.4±1.2 days for group B). Regarding to laboratory findings, their frequencies of neutropenia (<1,500/µL) were 16.0% for group A and 0.0% for group B ( P =0.011) and others did not show any significant differences. Conclusion: MP coinfection is not uncommon in hospitalized childhood influenza pneumonia and more common for older patients during early winter. These findings should be put into consideration for physician who care them. More prolonged and multi-hospital based studies should be done to clarify these conclusion.