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단일 지역사회병원에서 관찰된 혈청 아미노전이효소증가를 나타낸 소아 마이코플라스마 폐렴

Other Titles
 Pediatric Mycoplasma Pneumonia with Serum Transaminase Elevation at a Single Community Hospital 
 Newest Medical Journal (최신의학), Vol.55(2) : 11-22, 2012 
Journal Title
 Newest Medical Journal (최신의학) 
Issue Date
Transaminase ; Children ; Mycoplasma pneumonia
Purpose: Mycoplasma pneumoniae is an important cause of community acquired pneumonia and may cause extra-pulmonary manifestations but a few investigation for its liver involvement had been done. The object of this study is to know its recent hepatic manifestations and their effect on prognosis. Methods: I collected the clinical informations of 174 mycoplasma pneumonia patients who had been admitted at the Department of Pediatrics , Yongin Severance Hospital, Yongin, Korea from January 2008 to December 2010. Hepatic involvement cases were defined with serum transaminase level[ 40 IU/mL and over in serum asparate aminotransferase(AST) or 45 IU/ mL and over in alanine aminotransferase(ALT)]. Their clinical characteristics, demographics, laboratory findings, biochemical profiles, treatment outcomes were analysed and compared with no hepatic involvement cases. Results: There were fifty-five cases(31.6%) with serum transaminase elevation among mycoplasma pneumonia children. Thirty cases of them (54.5%) were observed at 2010 year. Their age was 3.3± 2.4 years old and twenty-seven cases(49.1%) were younger than 3 years old. Almost half of them(47.3%) were found in spring. Male to female ratio was 1:1.2. Their nonrespiratory symptoms and sign were loss of appetite(81.8%), nausea(58.2%), vomiting(40.0%), hepatomegaly(9.1%). Almost all of them(90.1%) showed AST elevation only. Their AST and ALT level were 63.7± 56.9 IU/L and 37.8± 68.9 IU/L, respectively. Forty-three cases(78.5%) were discharged within 5 days. The transaminase elevation of 48 cases(87.3%) was recovered within ten days. Patients with hepatic manifestation were significantly younger(P=0.004), more frequent in spring(P=0.039) and not longer admission duration than patients without it. They were comparable with each other in terms of fever, white blood cell counts, erythrocyte sedimentation rate, C-reactive protein elevation. Conclusion: It is frequently observed at very young age and in spring. Although it does not impact on prognosis, it should be kept in mind because its prevalence is not uncommon.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Seung Hwan(오승환) ORCID logo https://orcid.org/0000-0003-0829-0711
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