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Factors Associated with Lung Function Recovery at the First Year after Lung Transplantation

 Bo Ra Yoon  ;  Ji Eun Park  ;  Chi Young Kim  ;  Moo Suk Park  ;  Young Sam Kim  ;  Kyung Soo Chung  ;  Joo Han Song  ;  Hyo-Chae Paik  ;  Jin Gu Lee  ;  Song Yee Kim 
 Yonsei Medical Journal, Vol.59(9) : 1088-1095, 2018 
Journal Title
 Yonsei Medical Journal 
Issue Date
Adult ; Aged ; Female ; Forced Expiratory Volume/physiology* ; Humans ; Lung/physiopathology* ; Lung Diseases/etiology* ; Lung Diseases/mortality ; Lung Diseases/physiopathology* ; Lung Transplantation*/adverse effects ; Male ; Middle Aged ; Postoperative Complications/physiopathology ; Postoperative Period* ; Recovery of Function ; Republic of Korea/epidemiology ; Respiratory Function Tests/methods* ; Retrospective Studies ; Survival Analysis ; Time Factors
Lung transplantation ; forced expiratory volume in 1 second ; primary graft dysfunction
PURPOSE: Post-operative pulmonary function is an important prognostic factor for lung transplantation. The purpose of this study was to identify factors affecting recovery of forced expiratory volume in 1 second (FEV1) at the first year after lung transplantation. MATERIALS AND METHODS: We retrospectively reviewed the medical records of lung transplantation patients between October 2012 and June 2016. Patients who survived for longer than one year and who underwent pulmonary function test at the first year of lung transplantation were enrolled. Patients were divided into two groups according to whether they recovered to a normal range of FEV1 (FEV1 ≥80% of predicted value vs. <80%). We compared the two groups and analyzed factors associated with lung function recovery. RESULTS: Fifty-eight patients were enrolled in this study: 28 patients (48%) recovered to a FEV1 ≥80% of the predicted value, whereas 30 patients (52%) did not. Younger recipients [odds ratio (OR), 0.92; 95% confidence interval (CI), 0.87-0.98; p=0.010], longer duration of mechanical ventilator use after surgery (OR, 1.14; 95% CI, 1.03-1.26; p=0.015), and high-grade primary graft dysfunction (OR, 8.08; 95% CI, 1.67-39.18; p=0.009) were identified as independent risk factors associated with a lack of full recovery of lung function at 1 year after lung transplantation. CONCLUSION: Immediate postoperative status may be associated with recovery of lung function after lung transplantation.
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1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김송이(Kim, Song Yee) ORCID logo https://orcid.org/0000-0001-8627-486X
김영삼(Kim, Young Sam) ORCID logo https://orcid.org/0000-0001-9656-8482
김치영(Kim, Chi Young)
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
박지은(Park, Ji Eun)
백효채(Paik, Hyo Chae) ORCID logo https://orcid.org/0000-0001-9309-8235
송주한(Song, Joo Han)
윤보라(Yoon, Bo Ra)
이진구(Lee, Jin Gu)
정경수(Jung, Kyung Soo) ORCID logo https://orcid.org/0000-0003-1604-8730
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