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The Role of Cerebrovascular Disease in Amyloid Deposition

 Noh, Young  ;  Seo, Sang Won  ;  Jeon, Seun  ;  Lee, Jong Min  ;  Kim, Jae Seun  ;  Lee, Jae-Hong  ;  Kim, Jung-Hyun  ;  Kim, Geon Ha  ;  Ye, Byoung Seok  ;  Cho, Hanna  ;  Kim, Hee Jin  ;  Yoon, Cindy W  ;  Choe, Yearn Seong  ;  Lee, Kyung-Han  ;  Weiner, Michael W.  ;  Na, Duk L. 
 JOURNAL OF ALZHEIMERS DISEASE, Vol.54(3) : 1015-1026, 2016 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/psychology ; Cerebrovascular Disorders/diagnostic imaging* ; Cerebrovascular Disorders/psychology ; Cognitive Dysfunction/diagnostic imaging* ; Cognitive Dysfunction/psychology ; Dementia, Vascular/diagnostic imaging ; Dementia, Vascular/psychology ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Plaque, Amyloid/diagnostic imaging* ; Plaque, Amyloid/psychology ; Positron-Emission Tomography/methods ; Prospective Studies
Alzheimer’s disease ; cerebrovascular disease ; magnetic resonance imaging ; positron emission tomography ; vascular dementia
BACKGROUND: Some patients clinically diagnosed with subcortical vascular cognitive impairment (SVCI) have co-morbidity with AD pathology. OBJECTIVE: We investigated topographical differences in amyloid burden between SVCI and Alzheimer's disease type cognitive impairment (ADCI) using [11C] Pittsburgh compound B (PiB) positron emission tomography (PET). The purpose of this study was to investigate the role of cerebrovascular disease (CVD) in amyloid deposition. METHODS: We recruited 44 patients with SVCI and 44 patients with ADCI (amnestic mild cognitive impairment or Alzheimer's disease) with absent or minimal white matter hyperintensities, all with PiB-positive PET scans [PiB+]. As controls, we included 13 participants with normal cognition and PiB-negative scans. We divided the SVCI and ADCI patients into three groups according to global PiB retention ratio of SVCI, and then compared the tertiles in terms of the distribution of PiB retention using statistical parametric mapping analyses. Lobar to global PiB retention ratio and asymmetry indices were also compared between SVCI and ADCI groupsResults: Compared to PiB+ ADCI patients, PiB+ SVCI patients exhibited: 1) increased left-right asymmetry, and increased anterior-posterior difference; and 2) increased PiB retention in the parietal cortex, the occipital cortex and the precuneus-posterior cingulate cortex. In contrast, ADCI patients showed increased PiB retention in the striatum. When stratified by level of PiB retention, each group showed different characteristics. CONCLUSION: Our results showed that the distribution of amyloid deposition differed between patients with PiB+ SVCI and ADCI. These suggest that CVD contribute to and alter the known progression pattern in amyloid deposition in Alzheimer's disease.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
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