고밀도 지단백 콜레스테롤에 대한 중성지방의 비율과 안압 간의 상관관계

Abstract

Background: An elevated intraocular pressure (IOP) is shown to be associated with cardiometabolic risk factors such as age, sex, hypertension, diabetes mellitus, obesity and metabolic syndrome. The triglyceride (TG) to high density lipoprotein cholesterol (HDL-C) ratio has also been demonstrated to show a strong association with cardiometabolic disease. We aimed to investigate the association between IOP and the TG:HDL-C ratio in Koreans without glaucoma. Methods: We performed a cross-sectional study involving 7,244 participants who enrolled in a health examination program at the Gangnam Severance Hospital in Korea. Patients were divided into 4 equal groups based on the TG/HDL-C ratio and 2 groups based on IOP values with the difference between groups being 15 mmHg. Multiple logistic regression analysis was used to assess the relationship between a high IOP and the TG/HDL-C ratio after adjusting for age, sex, and total serum cholesterol values. Results: A significant relationship was observed between IOP and the TG/HDL-C ratio, and the mean IOP gradually increased in accordance with the quartile of the TG/HDL-C ratio (P<0.001). Multiple regression analysis showed that a high IOP was significantly associated with the highest quartile of the TG/HDL-C ratio after adjusting for age, sex, and total serum cholesterol (95% confidence interval, 1.098–1.545; P<0.01). Conclusion: A high TG/HDL-C ratio was independently associated with an elevated IOP in Koreans without glaucoma.