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Oncologic safety of breast-conserving surgery in breast cancer patients under the age of 35

 Incheon Kang  ;  Joo Heung Kim  ;  Seho Park  ;  Ho Hur  ;  Hyung Seok Park  ;  Seung Il Kim  ;  Young Up Cho 
 Korean Journal of Clinical Oncology (대한임상종양학회지), Vol.13(1) : 32-38, 2017 
Journal Title
 Korean Journal of Clinical Oncology (대한임상종양학회지) 
Issue Date
Purpose : Breast-conserving surgery (BCS) shows no difference in survival rates compared with total mastectomy. So, BCS is considered standard breast surgery with modified radical mastectomy. But in patients who received BCS, there is a risk of local recurrence in their long term follow up periods. Especially, BCS of young age is controversial regarding oncologic safety because of local recurrence. In this study, we struggle to confirm the oncologic safety of BCS compared with total mastectomy under the age of 35 in South Korea. Methods : All patients who underwent surgery for breast cancer were 5,366 at Severance Hospital, Yonsei University Health System, from January 1981 to April 2008. Of them, patients younger than 35 years old were 547. We excluded patients who received chemotherapy before surgery and included only stage 1 and 2 patients who identified through the pathology after surgery. Finally, we got 367 patients; total mastectomy was performed in 245 and BCS, in 122. We compared clinicopathological characteristics and oncologic outcomes between two groups using SPSS program. Results : In patients received BCS, a local recurrence rate was 7.7% at 5 years and up to 20.3% at 10 years. In patients received total mastectomy, a local recurrence rate was 1.9% over 10 years (P<0.001). However, there was no difference in 5-year and 10-year overall survival rates between two groups (P=0.689). Adjuvant chemotherapy decreased local recurrence rate in BCS patients (P=0.019). Conclusion : So, we concluded that BCS under the age of 35 has oncologic safety with undergoing chemotherapy.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Il(김승일)
Kim, Joo Heung(김주흥) ORCID logo https://orcid.org/0000-0002-0417-8434
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Cho, Young Up(조영업) ORCID logo https://orcid.org/0000-0003-2936-410X
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