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Comparison of characteristics in patients with both thyroid and breast cancer: Based on order of incidence

Authors
 Joo Heung Kim  ;  Incheon Kang  ;  Sanggeun Nam  ;  Hyung Seok Park  ;  Seho Park  ;  Jong Ju Jeong  ;  Kee-Hyun Nam  ;  Woong Youn Chung  ;  Seung Il Kim  ;  Young Up Cho  ;  Byeong-Woo Park 
Citation
 Korean Journal of Clinical Oncology (대한임상종양학회지), Vol.13(1) : 1-9, 2017 
Journal Title
 Korean Journal of Clinical Oncology (대한임상종양학회지) 
ISSN
 1738-8082 
Issue Date
2017
Keywords
Breast neoplasms ; Thyroid neoplasms ; Second primary neopla는 ; Survival rate
Abstract
Purpose : Clinicopathologic characteristics of patients with both thyroid and breast cancer during their lifetime were analyzed to investigate the association between the two malignancies according to the order of incidence. Methods : A total of 405 patients who underwent surgery for breast and thyroid cancer at Severance Hospital between 1995 and 2014 were retrospectively selected and classified into 3 groups according to the order of incidence of the two cancers: simultaneous cancer (S), thyroid cancer followed by breast cancer (TB), and breast cancer followed by thyroid cancer (BT). Univariate analysis was conducted to compare parameters. Results : S, TB, and BT groups were 166 (41.0%), 96 (23.7%), and 143 (35.3%) patients, respectively. In TB and BT groups, tumor size and surgical site for secondary cancer were smaller; therefore, adjuvant treatments were less frequently required for secondary cancer. ER positive rate was 77.1% in S, 75% in TB, and 63.7% in BT groups (P=0.027). The ratio of ER negative was higher in the group with BRAF mutation. Survival rate for index tumor was higher in order from TB, and BT, followed by S groups without statistical difference. Conclusion : It is difficult to find a significant difference according to the order of occurrence except by screening test, and more studies are needed in the future. Establishing an appropriate screening program is important in order to detect secondary breast or thyroid cancer after surgery for thyroid or breast cancer.
Files in This Item:
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DOI
10.14216/kjco.17001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
김승일(Kim, Seung Il)
남기현(Nam, Kee Hyun) ORCID logo https://orcid.org/0000-0002-6852-1190
박병우(Park, Byeong Woo) ORCID logo https://orcid.org/0000-0003-1353-2607
박세호(Park, Se Ho) ORCID logo https://orcid.org/0000-0001-8089-2755
정웅윤(Chung, Woung Youn)
정종주(Jeong, Jong Ju) ORCID logo https://orcid.org/0000-0002-4155-6035
조영업(Cho, Young Up) ORCID logo https://orcid.org/0000-0003-2936-410X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165992
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