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Comparison of characteristics in patients with both thyroid and breast cancer: Based on order of incidence

Authors
 Joo Heung Kim  ;  Incheon Kang  ;  Sanggeun Nam  ;  Hyung Seok Park  ;  Seho Park  ;  Jong Ju Jeong  ;  Kee-Hyun Nam  ;  Woong Youn Chung  ;  Seung Il Kim  ;  Young Up Cho  ;  Byeong-Woo Park 
Citation
 Korean Journal of Clinical Oncology (대한임상종양학회지), Vol.13(1) : 1-9, 2017 
Journal Title
Korean Journal of Clinical Oncology(대한임상종양학회지)
ISSN
 1738-8082 
Issue Date
2017
Keywords
Breast neoplasms ; Thyroid neoplasms ; Second primary neopla는 ; Survival rate
Abstract
Purpose : Clinicopathologic characteristics of patients with both thyroid and breast cancer during their lifetime were analyzed to investigate the association between the two malignancies according to the order of incidence.

Methods : A total of 405 patients who underwent surgery for breast and thyroid cancer at Severance Hospital between 1995 and 2014 were retrospectively selected and classified into 3 groups according to the order of incidence of the two cancers: simultaneous cancer (S), thyroid cancer followed by breast cancer (TB), and breast cancer followed by thyroid cancer (BT). Univariate analysis was conducted to compare parameters.

Results : S, TB, and BT groups were 166 (41.0%), 96 (23.7%), and 143 (35.3%) patients, respectively. In TB and BT groups, tumor size and surgical site for secondary cancer were smaller; therefore, adjuvant treatments were less frequently required for secondary cancer. ER positive rate was 77.1% in S, 75% in TB, and 63.7% in BT groups (P=0.027). The ratio of ER negative was higher in the group with BRAF mutation. Survival rate for index tumor was higher in order from TB, and BT, followed by S groups without statistical difference.

Conclusion : It is difficult to find a significant difference according to the order of occurrence except by screening test, and more studies are needed in the future. Establishing an appropriate screening program is important in order to detect secondary breast or thyroid cancer after surgery for thyroid or breast cancer.
Files in This Item:
T201706350.pdf Download
DOI
10.14216/kjco.17001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Il(김승일)
Kim, Joo Heung(김주흥) ORCID logo https://orcid.org/0000-0002-0417-8434
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Nam, Sanggeun(남상근)
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
Chung, Woong Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
Cho, Young Up(조영업) ORCID logo https://orcid.org/0000-0003-2936-410X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165992
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