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Ideal scaffold design for total ear reconstruction using a three-dimensional printing technique

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dc.contributor.author노태석-
dc.contributor.author정복기-
dc.contributor.author김영석-
dc.contributor.author김재윤-
dc.contributor.author윤인식-
dc.date.accessioned2018-12-03T01:59:15Z-
dc.date.available2018-12-03T01:59:15Z-
dc.date.issued2019-
dc.identifier.issn1552-4973-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165977-
dc.description.abstractEar reconstruction using three-dimensional (3D) printing technique has been considered as a good substitute for conventional surgery, because it can provide custom-made 3D framework. However, there are difficulties with its application in clinical use. Researchers have reported 3D scaffolds for ear cartilage regeneration, but the designs of the 3D scaffolds were not appropriate to be used in surgery. Hence, we propose the design of an ideal 3D ear scaffold for use in ear reconstruction surgery. Facial computed tomography (CT) images of the unaffected ear were extracted using a "segmentation" procedure. The selected data were converted to a 3D model and mirrored to create a model of the affected side. The design of 3D model was modified to apply to Nagata's two-stage surgery. Based on the 3D reconstructed model, a 3D scaffold was 3D printed using polycaprolactone. The 3D scaffold closely resembled the real cartilage framework used in current operations in terms of ear anatomy. To account for skin thickness, the 3D scaffold was made 4 mm smaller than the real ear. Furthermore, 2 mm pores were included to allow the implantation of diced cartilage to promote regeneration of the cartilage. 3D printing technology can overcome the limitations of previous auricular reconstruction methods. Further studies are required to achieve a functional and stable substitute for auricular cartilage and to extend the clinical use of the 3D-printed construct. Additionally, the ethical and legal issues regarding the transplantation of 3D-printed constructs and cell culture technologies using human stem cells remain to be solved.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherJohn Wiley & Sons-
dc.relation.isPartOfJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIdeal scaffold design for total ear reconstruction using a three-dimensional printing technique-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Plastic and Reconstructive Surgery (성형외과학교실)-
dc.contributor.googleauthorBok Ki Jung-
dc.contributor.googleauthorJae Yoon Kim-
dc.contributor.googleauthorYoung Seok Kim-
dc.contributor.googleauthorTai Suk Roh-
dc.contributor.googleauthorAnna Seo-
dc.contributor.googleauthorKeun‐Ho Park-
dc.contributor.googleauthorJin‐Hyung Shim-
dc.contributor.googleauthorIn Sik Yun-
dc.identifier.doi10.1002/jbm.b.34222-
dc.contributor.localIdA01297-
dc.contributor.localIdA04665-
dc.relation.journalcodeJ01267-
dc.identifier.eissn1552-4981-
dc.identifier.pmid30261122-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.34222-
dc.subject.keyword3D printing-
dc.subject.keywordauricular cartilage-
dc.subject.keywordauricular reconstruction-
dc.subject.keywordscaffold-
dc.contributor.alternativeNameRoh, Tai Suk-
dc.contributor.affiliatedAuthor노태석-
dc.contributor.affiliatedAuthor정복기-
dc.citation.volume107-
dc.citation.number4-
dc.citation.startPage1295-
dc.citation.endPage1303-
dc.identifier.bibliographicCitationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol.107(4) : 1295-1303, 2019-
dc.identifier.rimsid57844-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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