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Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

Authors
 Irina Matei  ;  Han Sang Kim  ;  David Lyden 
Citation
 Cell, Vol.170(2) : 223-225, 2017 
Journal Title
 Cell 
ISSN
 0092-8674 
Issue Date
2017
MeSH
Exosomes/genetics ; Humans ; Neoplasms/genetics* ; RNA*
Abstract
Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue ; Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors ; thereby promoting tumor growth and metastasis.
Files in This Item:
T201706239.pdf Download
DOI
10.1016/j.cell.2017.06.047
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Han Sang(김한상) ORCID logo https://orcid.org/0000-0002-6504-9927
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165925
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