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Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Authors
 Annette Becker  ;  Basant Kumar Thakur  ;  Joshua Mitchell Weiss  ;  Han Sang Kim  ;  Hector Peinado  ;  David Lyden 
Citation
 Cancer Cell, Vol.30(6) : 836-858, 2016 
Journal Title
 Cancer Cell 
ISSN
 1535-6108 
Issue Date
2016
Abstract
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly ; EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes ; such as coagulation ; vascular leakiness ; and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically ; EVs may be biomarkers and novel therapeutic targets for cancer progression ; particularly for predicting and preventing future metastatic development.
Files in This Item:
T201606793.pdf Download
DOI
10.1016/j.ccell.2016.10.009
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Han Sang(김한상) ORCID logo https://orcid.org/0000-0002-6504-9927
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165921
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