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Changes in neurocognitive function in patients with schizophrenia after starting or switching to amisulpride in comparison with the normal controls

 Yong Min Ahn  ;  Kyu Young Lee  ;  Chul-Eung Kim  ;  Jae-Jin Kim  ;  Dae-Yeob Kang  ;  Tae-Youn Jun  ;  Jin Sook Choi  ;  In-Won Chung  ;  Se Hyun Kim  ;  Samuel S.-H. Hwang  ;  Yong Sik Kim 
 Journal of Clinical Psychopharmacology, Vol.29(2) : 117-123, 2009 
Journal Title
 Journal of Clinical Psychopharmacology 
Issue Date
Adult ; Antipsychotic Agents/therapeutic use* ; Cognition Disorders/drug therapy* ; Cognition Disorders/etiology ; Female ; Follow-Up Studies ; Humans ; Male ; Neuropsychological Tests ; Schizophrenia/drug therapy* ; Schizophrenia/physiopathology ; Schizophrenic Psychology ; Sulpiride/analogs & derivatives* ; Sulpiride/therapeutic use ; Time Factors ; Trail Making Test ; Treatment Outcome ; Wechsler Scales ; Young Adult
We examined short- and long-term changes in neurocognitive functions in patients with schizophrenia who were either started or switched to amisulpride in comparison with the normal controls. Fifty-seven patients treated with amisulpride and 60 normal controls completed a comprehensive neurocognitive function test battery at the baseline, the 8-week, and the 1-year follow-up. We conducted and compared the results of both intention-to-treat (ITT) and per-protocol (PP) analyses to account for the follow-up loss. Three general results obtained were as follows: (1) the degree of the improvements in neurocognitive function was comparable to those of other second-generation antipsychotics in both ITT and PP analysis; (2) in light of the relative effect size, the composite effect size and the effect size in most measures in both ITT and PP analyses were smaller for the patient group than those of the control group, signifying that improvement in performance may be largely attributable to practice effects; and (3) nonetheless, there were evidences of both short- and long-term improvements in some cognitive tasks, such as in the Korean-Wechsler Adult Intelligence Scale vocabulary subtest and the Trail Making Test, that may not be accounted by practice effect. These results suggest the need to include a healthy control group to validate the medication effect of cognitive improvements in patients with schizophrenia and to consider practice effect in interpreting the results of repeated administration of neurocognitive function tests
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
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