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Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The Role of Reward System

Authors
 Jung Suk Lee  ;  Suwon Jung  ;  Il Ho Park  ;  Jae-Jin Kim 
Citation
 Current Neuropharmacology, Vol.13(6) : 750-759, 2015 
Journal Title
 Current Neuropharmacology 
ISSN
 1570-159X 
Issue Date
2015
MeSH
Anhedonia/physiology* ; Animals ; Brain/physiopathology* ; Humans ; Motivation/physiology* ; Reward ; Schizophrenia/diagnosis ; Schizophrenia/physiopathology* ; Schizophrenic Psychology*
Abstract
Anhedonia, the inability to feel pleasure, and amotivation, the lack of motivation, are two prominent negative symptoms of schizophrenia, which contribute to the poor social and occupational behaviors in the patients. Recently growing evidence shows that anhedonia and amotivation are tied together, but have distinct neural correlates. It is important to note that both of these symptoms may derive from deficient functioning of the reward network. A further analysis into the neuroimaging findings of schizophrenia shows that the neural correlates overlap in the reward network including the ventral striatum, anterior cingulate cortex and orbitofrontal cortex. Other neuroimaging studies have demonstrated the involvement of the default mode network in anhedonia. The identification of aspecific deficit in hedonic and motivational capacity may help to elucidate the mechanisms behind social functioning deficits in schizophrenia, and may also lead to more targeted treatment of negative symptoms
DOI
10.2174/1570159X13666150612230333
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165900
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