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정상 성인에서 양전자방출단층촬영을 통해 관찰한 무쾌감증 관련 뇌 영역

Other Titles
 Brain Regions Associated With Anhedonia in Healthy Adults: a PET Correlation Study 
 Young Chul Jung  ;  Jeong Ho Seok  ;  Jiwon Chun  ;  Hae-Jeong Park  ;  Jong Doo Lee  ;  Jae-Jin Kim 
 Korean Journal of Nuclear Medicine (대한핵의학회지), Vol.39(6) : 438-444, 2005 
Journal Title
 Korean Journal of Nuclear Medicine (대한핵의학회지) 
Issue Date
18F-FDG PET ; Anhedonia ; Positive affect trait ; Inferior temporal gyrus ; Prefrontal-cerebellar circuit
Purpose: Anhedonia has been proposed to be the result of a basic neurophysiologic dysfunction and a vulnerability marker that precede and contribute to the liability of developing schizophrenia. We hypothesized that anhedonia, as a construct reflecting the decreased capacity to experience pleasure, should be associated with decreased positive hedonic affect trait. This study examined the relationship between anhedonia and positive hedonic affect trait and searched for the brain regions which correlate with anhedonia in normal subjects. Materials and Methods: Using 18F-FDG PET scan, we investigated the brain activity of twenty one subjects during resting state. Questionnaires were administrated after the scan in order to assess the self-rated individual differences in physical/social anhedonia and positive/negative affect traits. Results: Negative correlation between physical anhedonia score and positive affect trait score was significant (Pearson coefficient=-0.440, p<0.05). The subjects' physical and social anhedonia scores showed positive correlation with metabolic rates in the cerebellum and negative correlation with metabolic rates in the inferior temporal gyrus and middle frontal gyrus. In addition, the positive affect trait score positively correlated with various areas, most prominent with the inferior temporal gyrus. Conclusion: These results suggest that neural substrates, such as the inferior temporal gyrus and prefrontal-cerebellar circuit, which dysfunction has been proposed to be involved with the cognitive deficits of schizophrenia, may also play a significant role in the liability of affective deficits like anhedonia.(Korean J Nucl Med 39(6):438-444, 2005)
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
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