Non-typhoidal salmonella is rarely the cause of pacemaker infection. A 68-year-old man was referred to our hospital with
tenderness and swelling at his cardiac resynchronization therapy defibrillator (CRT-D) implantation site. He had undergone CRT-D
implantation because of sustained ventricular tachycardia and heart failure 7 years earlier, and the generator had been changed 2
months earlier. Twenty-four years earlier, he had undergone aortic valve replacement and mitral valve repair. We removed the
generator and all of the CRT-D leads. After lead extraction, non-typhoidal salmonella serogroup B was cultured at the pocket and
lead tip. The patient was managed successfully with lead extraction and antibiotic therapy.