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베체트병 환자에서 아자티오프린 사용 중 나타난 와파린저항성 1예

Other Titles
 A Case of Azathioprine Induced Warfarin Resistance in Behçet’s Disease 
Authors
 김성렬  ;  임동우  ;  문일주  ;  고범석  ;  장명희  ;  유종하  ;  양희철  ;  이찬희 
Citation
 Journal of Rheumatic Diseases, Vol.22(4) : 242-245, 2015 
Journal Title
 Journal of Rheumatic Diseases 
ISSN
 2093-940X 
Issue Date
2015
Keywords
Behçet’s disease ; Azathioprine ; Warfarin ; Drug interactions
Abstract
Behçet’s disease is characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. Thrombosis associated with vascular inflammation in patients with Behçet’s disease presents various clinical symptoms. Warfarin is usually administered for treatment of thrombosis. However, warfarin can interact with many medications that cause various problems. A 43-year-old woman with Behçet’s disease presented with a swollen right leg. Deep vein thrombosis (DVT) was confirmed, and treated with warfarin. Due to exacerbation of Behçet’s disease, she received azathioprine along with warfarin. Subsequently, the international normalized ratio (INR) decreased and DVT was exacerbated. Despite an increase in the warfarin dose, the patient did not reach the target INR. After discontinuation of azathioprine, DVT improved and the warfarin dose was decreased. There were no specific findings associated with a hypercoagulable status. This finding suggests the interaction of azathioprine and warfarin. Therefore, clinicians should be cautious regarding the possibility of drug interactions between azathioprine and warfarin.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Beom Seok(고범석)
Kim, Sung Ryeol(김성렬) ORCID logo https://orcid.org/0000-0001-7418-0049
Moon, Il Joo(문일주)
Leem, Dong Woo(임동우)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165823
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