신기능 저하가 없는 한국 중년 성인에서 커피 섭취량과 평가 사구체 여과율의 관계: 국민건강영양조사 2013-2014년

Abstract

Background: Previous studies have suggested that anti-inflammatory and anti-oxidative effect of caffeine has an influence on renal function. However, the effect of coffee consumption on estimated glomerular filtration rate (eGFR) without renal impairment has not been investigated. The aim of this study was to evaluate the association between coffee consumption and eGFR in middle-aged Koreans without renal impairment using data from a representative nationwide survey. Methods: This was a cross-sectional study conducted in Koreans aged 45 to 64 years, who enrolled for the sixth Korea National Health and Nutrition Examination Surveys 2013–2014. The participants were classified into three groups based on the amount of coffee consumption as reported on the food frequency questionnaire: (specify) category 1, 2, and 3. eGFR calculated using the Modification of Diet in Renal Disease equation was used for evaluation of kidney function. Results: In all the three categories of daily coffee consumption, eGFR showed a significant increase with the increase in coffee consumption in middle-aged Korean women (P=0.006). However, no such trend was observed in middle-aged Korean men. In middle-aged women, eGFR increased significantly in individuals consuming ≥2 cups per day, compared with those consuming <1 cup per day, after adjusting for other compounding factors (β=2.614, P=0.041). Conclusion: Coffee consumption and estimated glomerular filtration rate showed a significant positive relationship only in middle-aged Korean women consuming ≥2 cups coffee per day.