Cited 8 times in
Anti-IgM induces up-regulation and tyrosine-phosphorylation of heterogeneous nuclear ribonucleoprotein K proteins (hnRNP K) in a Ramos B cell line.
DC Field | Value | Language |
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dc.contributor.author | 박전한 | - |
dc.date.accessioned | 2018-11-22T16:56:07Z | - |
dc.date.available | 2018-11-22T16:56:07Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165733 | - |
dc.description.abstract | Heterogeneous nuclear ribonucleoprotein K protein (hnRNP K) has diverse molecular partners implicated in signal transduction pathways, and is tyrosine-phosphorylated in response to growth factors and oxidative stress. Among the structurally distinct domains of hnRNP K, an SH3-binding domain (SH3BD) has been known to promote the association of SH3-containing tyrosine kinases and protooncoprotein Vav, which are involved in B cell receptor (BCR) signalling. In this study, we analyzed proteins of Ramos B cell line that are altered upon BCR activation with anti-IgM antibody, revealing that a certain hnRNP K isoform is up-regulated in response to anti-IgM treatment. We also showed that hnRNP K is tyrosine-phosphorylated after BCR ligation. HnRNP K lacking the SH3BD is shown not to interact with phosphorylated Vav, and Ramos cells stably expressing this mutant protein are less susceptible to anti-IgM-induced apoptosis, indicating that hnRNP K is coupled to BCR-mediated signalling and its SH3BD is required for proper signal propagation. Our results provide the first evidence that hnRNP K is involved in BCR signalling pathway. | - |
dc.language | English | - |
dc.publisher | Elsevier/North-Holland Biomedical Press | - |
dc.relation.isPartOf | IMMUNOLOGY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Anti-IgM induces up-regulation and tyrosine-phosphorylation of heterogeneous nuclear ribonucleoprotein K proteins (hnRNP K) in a Ramos B cell line. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Hye-Kyung Jeon | - |
dc.contributor.googleauthor | Jeong-Hun Ahn | - |
dc.contributor.googleauthor | Jongseon Choe | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Tae H. Lee | - |
dc.identifier.doi | 10.1016/j.imlet.2004.12.005 | - |
dc.contributor.localId | A01641 | - |
dc.relation.journalcode | J01038 | - |
dc.identifier.eissn | 1879-0542 | - |
dc.identifier.pmid | 15860232 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0165247804003700 | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.affiliatedAuthor | 박전한 | - |
dc.citation.volume | 98 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 303 | - |
dc.citation.endPage | 310 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY LETTERS, Vol.98(2) : 303-310, 2005 | - |
dc.identifier.rimsid | 58334 | - |
dc.type.rims | ART | - |
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