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Prognostic Impact of Immunonutritional Status Changes During Preoperative Chemoradiation in Patients With Rectal Cancer.

Authors
 Yong Joon Lee  ;  Woo Ram Kim  ;  Jeonghee Han  ;  Yoon Dae Han  ;  Min Soo Cho  ;  Hyuk Hur  ;  Kang Young Lee  ;  Nam Kyu Kim  ;  Byung Soh Min 
Citation
 Annals of Coloproctology, Vol.32(6) : 208-214, 2016 
Journal Title
 Annals of Coloproctology 
ISSN
 2287-9714 
Issue Date
2016
Keywords
Immunonutritional status ; Preoperative chemoradiation ; Prognostic nutritional index ; Rectal neoplasms
Abstract
PURPOSE: Previous studies have demonstrated the prognostic impact of the prognostic nutritional index (PNI), a proposed indicator of immunonutritional statuses of surgical patients, on patients with various gastrointestinal cancers. Although the prognostic impact of the PNI on patients with colorectal cancer has been well established, its value has not been studied in patients treated with preoperative chemoradiation (pCRT). This study aimed to evaluate the prognostic impact of PNI on patients receiving pCRT for locally advanced rectal cancer (LARC). METHODS: Patients with LARC who underwent curative pCRT followed by surgical resection were enrolled. The PNI was measured in all patients before and after pCRT, and the difference in values was calculated as the PNI difference (dPNI). Patients were classified according to dPNI (<5, 5-10, and >10). Clinicopathologic parameters and long-term oncologic outcomes were assessed according to dPNI classification. RESULTS: No significant intergroup differences were observed in clinicopathologic parameters such as age, histologic grade, tumor location, tumor-node-metastasis stage, and postoperative complications. Approximately 53% of the patients had a mild dPNI (<5); only 15% had a high dPNI (>10). Univariate and multivariate analyses identified the dPNI as an independent prognostic factor for disease-free status (P < 0.01; hazard ratio [HR], 2.792; 95% confidence interval [CI], 1.577-4.942) and for cancer-specific survival (P = 0.012; HR, 2.469; 95%CI, 1.225-4.978). CONCLUSION: The dPNI is predictive of long-term outcomes in pCRT-treated patients with LARC. Further prospective studies should investigate whether immune-nutritional status correction during pCRT would improve oncologic outcomes.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165667
Files in This Item:
T999900220.pdf Download
DOI
10.3393/ac.2016.32.6.208
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김남규(Kim, Nam Kyu) ORCID logo https://orcid.org/0000-0003-0639-5632
김우람(Kim, Woo Ram)
민병소(Min, Byung Soh)
조민수(Cho, Min Soo)
한윤대(Han, Yoon Dae) ORCID logo https://orcid.org/0000-0002-2136-3578
허혁(Hur, Hyuk) ORCID logo https://orcid.org/0000-0002-9864-7229
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