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Age-related Contribution of Lp (a) with Coronary Artery Calcification in Patients with Acute Coronary Syndrome: a Potential Role of Metabolic Disorder in Calcified Plaque

Authors
 Sung Kee Ryu  ;  Bum Kee Hong  ;  Hyuck Moon Kwon  ;  Wook Jin Chung  ;  Byoung Eun Park  ;  Dong Yeon Kim  ;  Yun Hyeong Cho  ;  Se Jung Yoon  ;  Young Won Yoon  ;  Seung Yun Cho  ;  Hyun Seung Kim 
Citation
 Yonsei Medical Journal, Vol.44(3) : 445-453, 2003 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2003
MeSH
Acute Disease ; Age Factors ; Aged ; Aging/blood* ; Calcinosis/blood ; Calcinosis/complications* ; Coronary Artery Disease/blood ; Coronary Artery Disease/etiology* ; Coronary Vessels/pathology* ; Female ; Humans ; Lipoprotein(a)/blood* ; Male ; Metabolic Diseases/complications ; Middle Aged ; Risk Factors ; Syndrome
Abstract
Lp(a) and coronary artery calcification (CAC) have recently been reported as predictors of plaque instability, but this is surrounded by much controversy. We investigated the influence of Lp(a) and CAC compared other acute coronary syndrome (ACS) risk factors. 698 patients diagnosed with at least minimal coronary artery obstructive disease from a coronary angiography were randomly selected using SPSS. Lp(a), other lipid profiles and past histories were checked, and CAC semi quantitatively graded on stored fluoroscopic images. The prevalence of CAC was significantly higher in the ACS than the non-ACS group (38.0% vs. 29.9%, p=0.026). The serum level of Lp(a) (26.89 +/- 30.64 vs. 20.85 +/- 21.63, p < 0.01) and prevalence of positive Lp(a) (> 35 mg/dl) was higher in the ACS group (24% vs. 15.7%, p < 0.01). The risk of ACS was higher in the patients with both CAC and elevated an Lp(a) than in those with only one (OR: 2.16, p=0.009, 95% CI; 1.213 - 3.843 vs. OR: 1.79, p < 0.001, 95% CI; 1.300 - 2.456). The risk of ACS was increased 1.451 times (p=0.040, 95% CI; 1.071- 2.071) in patients with CAC and 1.648 times (p=0.014, 95% CI; 1.107- 2.455) in patients with a Lp(a) > 35 mg/dl. In the younger patients (< 60 years), the Lp(a), but not the CAC, was an independent risk factor for ACS (OR=2.248, p=0.005, 95% CI; 1.281-3.943). In the older patients (> 60 years), CAC, but not the Lp(a), was an independent risk factor (OR=1.775, p=0.021, 95% CI; 1.090 - 2.890). Both the Lp(a) and CAC were risk factors for ACS, and they had a synergistic effect on its development. In the younger Lp(a), and the older CAC, was the more potent risk factor for ACS, respectively.
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DOI
10.3349/ymj.2003.44.3.445
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
권혁문(Kwon, Hyuck Moon) ORCID logo https://orcid.org/0000-0001-9901-5015
홍범기(Hong, Bum Kee) ORCID logo https://orcid.org/0000-0002-6456-0184
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165648
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