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Serum Chemerin Levels are Associated with Visceral Adiposity, Independent of Waist Circumference, in Newly Diagnosed Type 2 Diabetic Subjects

 Dae Young Cheon  ;  Jun Goo Kang  ;  Seong Jin Lee  ;  Sung Hee Ihm  ;  Eun Jig Lee  ;  Moon Gi Choi  ;  Hyung Joon Yoo  ;  Chul Sik Kim 
 YONSEI MEDICAL JOURNAL, Vol.58(2) : 319-325, 2017 
Journal Title
Issue Date
Adiposity ; Adult ; Biomarkers/blood ; Body Mass Index ; C-Reactive Protein/metabolism ; Chemokines/blood ; Chemokines/metabolism ; Cholesterol, HDL/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Female ; Humans ; Insulin Resistance ; Intercellular Signaling Peptides and Proteins ; Intra-Abdominal Fat* ; Male ; Metabolic Syndrome/complications ; Middle Aged ; Obesity/complications ; Triglycerides/blood ; Waist Circumference*
Chemerin ; type 2 diabetes mellitus ; visceral fat
PURPOSE: Chemerin has been suggested to be linked to insulin resistance and type 2 diabetes mellitus (T2DM). However, the relationship between visceral adiposity and chemerin levels remains unclear in subjects with T2DM. In this study, we investigated the relationship between serum chemerin levels and visceral adiposity. MATERIALS AND METHODS: This study included 102 subjects newly diagnosed with T2DM. The relationships between serum chemerin levels and clinical and biochemical parameters were examined. Multiple linear regression analysis was performed to determine the predictable factors of serum chemerin levels. RESULTS: Serum chemerin levels showed significant positive correlations with body mass index (BMI), waist circumference (WC), visceral fat thickness (VFT), insulin levels, the homeostasis model assessment of insulin resistance, and levels of triglycerides (log-transformed) and high-sensitivity C-reactive protein, while showing significant negative correlations with high-density lipoprotein cholesterol. After adjusting for BMI and WC, VFT showed a significant relationship with serum chemerin levels (r=0.222, p=0.027). Moreover, VFT was an independent predictive factor of serum chemerin levels (β=0.242, p=0.041). CONCLUSION: We demonstrated that chemerin is linked to metabolic syndrome components. Moreover, serum chemerin levels were associated significantly with obesity, especially visceral adipose tissue, in subjects with T2DM.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
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