Countries that ratified the World Health Organization Framework Convention on Tobacco Control (FCTC) have an obligation to protect people from exposure to tobacco smoke in all indoor places. Methods/Statistical analysis: In order to identify the bases of economic or other impacts of the increased number of non-smoking zones, Whitlock's (2008) systematic literature review method was adopted. With the key question of What kinds of changes can the designation and expansion of non-smoking areas make the review used Ovid-Medline and CENTRAL as databases for the literature search while utilizing DB pia, KoreaMed, Riss, NDSL, KISS for the domestic literature search. Findings: The systematic literature review suggested that all businesses, except for bars, showed generally positive economic impacts resulting from expansion of non-smoking zones, though there were some discrepancies across different business types. These results were more distinct in studies funded by organizations unrelated to tobacco companies and those of high-quality research.