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Cyclophosphamide 연관 중증 심부전을 동반한 Cardiomyopathy 환자에서 치료 후 회복된 증례

Other Titles
 A Case of Successfully Treated Severe Heart Failure .due to Cyclophosphamide Induced Cardiomyopathy 
Authors
 Jung Min Park  ;  Seung Min Hahn  ;  Jung Woo Han  ;  Chuhl Joo Lyu 
Citation
 Clinical Pediatric Hematology-Oncology, Vol.25(1) : 71-75, 2018 
Journal Title
 Clinical Pediatric Hematology-Oncology 
ISSN
 2233-5250 
Issue Date
2018
Keywords
Cyclophosphamide ; Cardiomyopathy ; Chemotherapy
Abstract
Cyclophosphamide-induced cardiotoxicity is an uncommon complication especially in patients who have never undergone mediastinal irradiation or cardiotoxic chemotherapy and do not have underlying cardiac diseases. Here, we describe the case of a 19-year-old female with chronic myeloid leukemia. She was previously treated with oral tyrosine kinase inhibitors and developed cardiomyopathy after receiving infusion of 60 mg/kg intravenous cyclophosphamide for two days with a conditioning regimen for allogenic hematopoietic stem cell transplantation. Severe thickening of the left ventricle and reduced ejection fraction without triggering agents were characteristic for cyclophosphamide-induced cardiomyopathy. Her NT-pro BNP and troponin T concentrations surged to >70,000 pg/mL (0=130 pg/mL) and 2,031 pg/mL (0-14 pg/mL), respectively, during the course of the therapy and multiple organ failure seemed imminent evidenced by unresponsive decline in blood pressure. However, with close monitoring and persistent conservative management which consisted of intravenous hydration, continuous hemodialysis, and mechanical ventilation, her condition recovered.
Files in This Item:
T201804216.pdf Download
DOI
10.15264/cpho.2018.25.1.71
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
유철주(Lyu, Chuhl Joo) ORCID logo https://orcid.org/0000-0001-7124-7818
한승민(Hahn, Seung Min) ORCID logo https://orcid.org/0000-0001-9832-6380
한정우(Han, Jung Woo) ORCID logo https://orcid.org/0000-0001-8936-1205
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165575
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