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Effectiveness of the polysaccharide hemostatic powder in non-variceal upper gastrointestinal bleeding: Using propensity score matching.

 Jun Chul Park  ;  Yeong Jin Kim  ;  Eun Hye Kim  ;  Jinae Lee  ;  Hyun Su Yang  ;  Eun Hwa Kim  ;  Kyu Yeon Hahn  ;  Sung Kwan Shin  ;  Sang Kil Lee  ;  Yong Chan Lee 
 Journal of Gastroenterology and Hepatology, Vol.33(8) : 1500-1506, 2018 
Journal Title
 Journal of Gastroenterology and Hepatology 
Issue Date
Aged ; Aged, 80 and over ; Endoscopy, Gastrointestinal ; Feasibility Studies ; Gastrointestinal Hemorrhage/drug therapy* ; Hemostatic Techniques* ; Hemostatics/administration & dosage* ; Humans ; Middle Aged ; Polysaccharides/administration & dosage* ; Powders ; Propensity Score ; Recurrence ; Retrospective Studies ; Time Factors ; Treatment Outcome
endoclot ; non-variceal upper gastrointestinal bleeding ; polysaccharide hemostatic powder
BACKGROUND AND AIM: Recently, the application of hemostatic powder to the bleeding site has been used to treat active upper gastrointestinal bleeding (UGIB). We aimed to assess the effectiveness of the polysaccharide hemostatic powder (PHP) in patients with non-variceal UGIB. METHODS: We reviewed prospectively collected 40 patients with UGIB treated with PHP therapy between April 2016 and January 2017 (PHP group) and 303 patients with UGIB treated with conventional therapy between April 2012 and October 2014 (conventional therapy group). We compared the rate of successful hemostasis and the rebleeding between the two groups after as well as before propensity score matching using the Glasgow-Blatchford score and Forrest classification. RESULTS: Thirty patients treated with the PHP and 60 patients treated with conventional therapy were included in the matched groups. Baseline patient characteristics including comorbidities, vital signs, and bleeding scores were similar in the matched groups. The rate of immediate hemostasis and 7-day and 30-day rebleeding were also similar in the two groups before and after matching. In the subgroup analysis, no significant differences in immediate hemostasis or rebleeding rate were noted between PHP in monotherapy and PHP combined with a conventional hemostatic method. At 30 days after the therapy, there were no significant PHP-related complications or mortality. CONCLUSIONS: Given its safety, the PHP proved feasible for endoscopic treatment of UGIB, having similar effectiveness as that of conventional therapy. The PHP may become a promising hemostatic method for non-variceal UGIB.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김영진(Kim, Young Jin)
김은혜(Kim, Eun Hye) ORCID logo https://orcid.org/0000-0001-6691-6837
박준철(Park, Jun Chul) ORCID logo https://orcid.org/0000-0001-8018-0010
신성관(Shin, Sung Kwan)
이상길(Lee, Sang Kil) ORCID logo https://orcid.org/0000-0002-0721-0364
이용찬(Lee, Yong Chan)
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