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Difference between right-sided and left-sided colorectal cancers: from embryology to molecular subtype.

Authors
 Seung Yoon Yang  ;  Min Soo Cho  ;  Nam Kyu Kim 
Citation
 EXPERT REVIEW OF ANTICANCER THERAPY, Vol.18(4) : 351-358, 2018 
Journal Title
 EXPERT REVIEW OF ANTICANCER THERAPY 
ISSN
 1473-7140 
Issue Date
2018
Keywords
Colorectal cancer ; hindgut ; location ; metastatic ; midgut ; prognostic
Abstract
Colorectal cancer is one of the most common malignancies in the world, and it exhibits differences in incidence, pathogenesis, molecular pathways, and outcome depending on the location of the tumor. Differences in the microbiome, clinical characteristics, and chromosomal and molecular characteristics have been reported between the right and left side of the colon. Areas covered: This review focuses on the latest developments in epidemiological and chromosomal and molecular studies, which have enhanced our understanding on the underlying genetic and immunological differences between the right-sided colon and the left-sided colorectum in metastatic colorectal cancer. Expert commentary: The numerous findings regarding differences between right- and left-sided colon cancers should have an impact on colorectal cancer screening and therapy. The location of the colorectal cancer should be considered before group stratification into genetic, clinical, and especially chemotherapy trials. A more tailored approach to colon cancer treatment would be highly desirable if future trials further support the hypothesis of two distinct tumor entities.
Full Text
https://www.tandfonline.com/doi/full/10.1080/14737140.2018.1442217
DOI
10.1080/14737140.2018.1442217
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Yang, Seung Yoon(양승윤) ORCID logo https://orcid.org/0000-0001-8129-7712
Cho, Min Soo(조민수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165519
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