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Chitotriosidase inhibits allergic asthmatic airways via regulation of TGF-β expression and Foxp3+ Treg cells.

DC Field Value Language
dc.contributor.author김경원-
dc.contributor.author김미나-
dc.contributor.author설인숙-
dc.contributor.author손명현-
dc.contributor.author홍정연-
dc.date.accessioned2018-11-16T16:57:38Z-
dc.date.available2018-11-16T16:57:38Z-
dc.date.issued2018-
dc.identifier.issn0105-4538-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165514-
dc.description.abstractBACKGROUND: Chitotriosidase (chitinase 1, Chit1), a major true chitinase in humans, is induced in childhood asthma and has been implicated in the pathogenesis of a variety of inflammatory and tissue remodeling responses. However, the role and the mechanisms that underlie these contributions to the diseases have not been defined. We hypothesized that Chit1 plays a significant role in the pathogenesis of allergic asthma. METHODS: Wild-type and Chit1-deficient mice and cells in culture were used to define the roles of Chit1 in models of allergic adaptive Th2 inflammation. In addition, the levels of sputum Chit1 were evaluated in pediatric asthma patients and compared to control. RESULTS: The levels of sputum Chit1 were significantly increased in the patients with childhood asthma. Mice with Chit1 null mutation demonstrated enhanced allergic Th2 inflammatory and cytokine and IgE responses to OVA or house dust mite allergen sensitization and challenge. However, the expression levels of TGF-β1 were significantly decreased with a diminished number of Foxp3+ regulatory T cells (Treg) in the lungs of Chit1-/- mice compared to WT controls. In vitro, the absence of Chit1 significantly reduced TGF-β-stimulated conversion of CD4+ CD25- naïve T cells to CD4+ Foxp3+ Treg cells, suggesting Chit1 is required for optimal effect of TGF-β1 in Treg cell differentiation. CONCLUSION: Chit1 plays a protective role in the pathogenesis of allergic inflammation and asthmatic airway responses via regulation of TGF-β expression and Foxp3+ Treg cells.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfALLERGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleChitotriosidase inhibits allergic asthmatic airways via regulation of TGF-β expression and Foxp3+ Treg cells.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorJ. Y. Hong-
dc.contributor.googleauthorM. Kim-
dc.contributor.googleauthorI. S. Sol-
dc.contributor.googleauthorK. W. Kim-
dc.contributor.googleauthorC.‐M. Lee-
dc.contributor.googleauthorJ. A. Elias-
dc.contributor.googleauthorM. H. Sohn-
dc.contributor.googleauthorC. G. Lee-
dc.identifier.doi10.1111/all.13426-
dc.contributor.localIdA00303-
dc.contributor.localIdA00441-
dc.contributor.localIdA01941-
dc.contributor.localIdA01967-
dc.contributor.localIdA04431-
dc.relation.journalcodeJ00062-
dc.identifier.eissn1398-9995-
dc.identifier.pmid29420850-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/all.13426-
dc.subject.keywordTGF-beta1-
dc.subject.keywordTh2 response-
dc.subject.keywordasthma-
dc.subject.keywordchitotriosidase-
dc.subject.keywordregulatory T cell-
dc.contributor.alternativeNameKim, Kyung Won-
dc.contributor.alternativeNameKim, Mina-
dc.contributor.alternativeNameSol, In Suk-
dc.contributor.alternativeNameSon, Myung Hyun-
dc.contributor.alternativeNameHong, Jung Yeon-
dc.contributor.affiliatedAuthor김경원-
dc.contributor.affiliatedAuthor김미나-
dc.contributor.affiliatedAuthor설인숙-
dc.contributor.affiliatedAuthor손명현-
dc.contributor.affiliatedAuthor홍정연-
dc.citation.volume73-
dc.citation.number8-
dc.citation.startPage1686-
dc.citation.endPage1699-
dc.identifier.bibliographicCitationALLERGY, Vol.73(8) : 1686-1699, 2018-
dc.identifier.rimsid59125-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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