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In vivo skin reactions from pulsed-type, bipolar, alternating current radiofrequency treatment using invasive noninsulated electrodes.

Authors
 S.B. Cho  ;  J. Na  ;  Z. Zheng  ;  J.M. Lim  ;  J.‐S. Kang  ;  J.H. Lee  ;  S.E. Lee 
Citation
 Skin Research and Technology, Vol.24(2) : 318-325, 2018 
Journal Title
 Skin Research and Technology 
ISSN
 0909-752X 
Issue Date
2018
Keywords
alternating current ; basement membrane ; bipolar ; blood vessel ; invasive ; microneedle ; pulsed-type radiofrequency
Abstract
BACKGROUND: Bipolar, alternating current radiofrequency (RF) conduction using invasive noninsulated electrodes consecutively generates independent tissue coagulation around each electrode and then, the converged coagulation columns. METHODS: Two pulsed-type RF models at the on-time pulse width/pulse pack of 30 and 40 milliseconds were designed to amplify the early stage of RF-induced tissue reaction using hairless mouse skin in vivo. Then, structural and ultrastructural changes were evaluated in hairless mouse skin samples at baseline and immediately 1 day, 3 days, 7 days, and 14 days after treatment. RESULTS: Immediately after pulsed-RF treatment, a few chrysanthemum-like zones of electrothermal coagulation and hypereosinophilic collagen fibers were found in the dermis and dermo-subcutaneous fat junction. Histochemical staining for periodic acid-Schiff and immunohistochemical staining for type IV collagen revealed marked thickening of basement membranes. Transmission electron microscopy demonstrated that pulsed-RF treatment resulted in higher electron-dense and remarkably thicker lamina densa, as well as increases in anchoring fibrils, compared with untreated control specimens. Furthermore, CD31-positive blood vessels were smaller in size with a slit-like luminal appearance, without excessive damage to endothelial cells. CONCLUSION: Our data indicated that pulse-type, bipolar RF energy induces structural and ultrastructural changes in basement membranes and vascular components in hairless mouse skin.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/srt.12433
DOI
10.1111/srt.12433
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Eun(이상은) ORCID logo https://orcid.org/0000-0003-4720-9955
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165421
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