Cited 9 times in
Lipidomic differentiation of Graves' ophthalmopathy in plasma and urine from Graves' disease patients.
DC Field | Value | Language |
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dc.contributor.author | 구철룡 | - |
dc.contributor.author | 신동엽 | - |
dc.contributor.author | 윤진숙 | - |
dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2018-11-16T16:52:05Z | - |
dc.date.available | 2018-11-16T16:52:05Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1618-2642 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165409 | - |
dc.description.abstract | Approximately 50% of patients with Graves' disease (GD) develop retracted eyelids with bulging eyes, known as Graves' ophthalmopathy (GO). However, no simple diagnostic blood marker for distinguishing GO from GD has been developed yet. The objective of this study was to conduct comprehensive profiling of lipids using plasma and urine samples from patients with GD and GO undergoing antithyroid therapy using nanoflow ultrahigh performance liquid chromatography electrospray ionization tandem mass spectrometry. Plasma (n = 86) and urine (n = 75) samples were collected from 23 patients with GD without GO, 31 patients with GO, and 32 healthy controls. Among 389 plasma and 273 urinary lipids that were structurally identified, 281 plasma and 191 urinary lipids were quantified in selected reaction monitoring mode. High-abundance lipids were significantly altered, indicating that the development of GD is evidently related to altered lipid metabolism in both plasma and urine. Several urinary lysophosphatidylcholine species were found to be increased (3- to 10-fold) in both GD and GO. While the overall lipid profiles between GD and GO were similar, significant changes (area under receiver operating curve > 0.8) in GO vs. GD were observed in a few lipid profiles: 58:7-TG and (16:1,18:0)-DG from plasma, 16:1-PC and 50:1-TG from urine, and d18:1-S1P from both plasma and urine samples. An altered metabolism of lipids associated with the additional development of ophthalmopathy was confirmed with the discovery of several candidate markers. These can be suggested as candidate markers for differentiating the state of GO and GD patients based on plasma or urinary lipidomic analysis. Graphical abstract. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | ANALYTICAL AND BIOANALYTICAL CHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Chromatography, High Pressure Liquid/methods | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Graves Ophthalmopathy/blood* | - |
dc.subject.MESH | Graves Ophthalmopathy/diagnosis | - |
dc.subject.MESH | Graves Ophthalmopathy/metabolism | - |
dc.subject.MESH | Graves Ophthalmopathy/urine* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipid Metabolism | - |
dc.subject.MESH | Lipids/blood* | - |
dc.subject.MESH | Lipids/urine* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolomics/methods | - |
dc.subject.MESH | Spectrometry, Mass, Electrospray Ionization/methods | - |
dc.subject.MESH | Tandem Mass Spectrometry/methods | - |
dc.title | Lipidomic differentiation of Graves' ophthalmopathy in plasma and urine from Graves' disease patients. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seul Kee Byeon | - |
dc.contributor.googleauthor | Se Hee Park | - |
dc.contributor.googleauthor | Jong Cheol Lee | - |
dc.contributor.googleauthor | Sena Hwang | - |
dc.contributor.googleauthor | Cheol Ryong Ku | - |
dc.contributor.googleauthor | Dong Yeob Shin | - |
dc.contributor.googleauthor | Jin Sook Yoon | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Myeong Hee Moon | - |
dc.identifier.doi | 10.1007/s00216-018-1313-2 | - |
dc.contributor.localId | A00201 | - |
dc.contributor.localId | A02093 | - |
dc.contributor.localId | A02611 | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J00132 | - |
dc.identifier.eissn | 1618-2650 | - |
dc.identifier.pmid | 30135996 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00216-018-1313-2 | - |
dc.subject.keyword | Graves’ disease | - |
dc.subject.keyword | Lipidomic analysis | - |
dc.subject.keyword | Ophthalmopathy | - |
dc.subject.keyword | Plasma | - |
dc.subject.keyword | Urine | - |
dc.subject.keyword | nUPLC-ESI-MS/MS | - |
dc.contributor.alternativeName | Ku, Cheol Ryong | - |
dc.contributor.alternativeName | Shin, Dong Yeob | - |
dc.contributor.alternativeName | Yoon, Jin Sook | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | 구철룡 | - |
dc.contributor.affiliatedAuthor | 신동엽 | - |
dc.contributor.affiliatedAuthor | 윤진숙 | - |
dc.contributor.affiliatedAuthor | 이은직 | - |
dc.citation.volume | 410 | - |
dc.citation.number | 27 | - |
dc.citation.startPage | 7121 | - |
dc.citation.endPage | 7133 | - |
dc.identifier.bibliographicCitation | ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol.410(27) : 7121-7133, 2018 | - |
dc.identifier.rimsid | 58874 | - |
dc.type.rims | ART | - |
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