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Different biological behaviors in left-sided pancreatic cancer according to Yonsei criteria: Proposal of a modified Yonsei criteria score.

Authors
 Seoung Yoon Rho  ;  Mijin Yun  ;  Chang Moo Kang  ;  Sung Hwan Lee  ;  Ho Kyoung Hwang  ;  Woo Jung Lee 
Citation
 Pancreatology, : epub., 2018 
Journal Title
 Pancreatology 
ISSN
 1424-3903 
Issue Date
2018
Keywords
Laparoscopic distal pancreatectomy ; PET-CT ; Pancreatic cancer ; SUV(max) ; Yonsei criteria
Abstract
BACKGROUND/OBJECTIVES: Our institutional experience has demonstrated that bloodless and margin-negative resection is the most potent prognostic factor in treating left-sided pancreatic cancer and we developed selection guideline. The Yonsei criteria (YC) is selection criteria for oncologically safe and effective resection of left-sided pancreatic cancer by a minimally invasive approach. In this study, we investigated whether left-sided pancreatic cancer with YC can be more individualized to predict long-term survival by using clinically and pathologically detectable parameters. METHODS: From January 2000 to December 2015, 105 patients underwent distal pancreatectomy for left-sided pancreatic cancer. The medical records of the patients were retrospectively reviewed. RESULTS: Among clinically and pathologically detectable parameters to predict tumor conditions, radiologically determined tumor size (p = 0.080) and SUVmax (p = 0.086) were identified as predictors of early tumor recurrence with marginal significance. Among them, 20% of the patients with YC were identified as having the most favoring tumor condition, with an modified YC score of 3. The patient group with the lowest mYC score was found to have a very long disease-free survival time, with a mean of 108 months, which was statistically different from those with other mYC scores (mYC score = 4, mean 47.1 months [95% CI: 27.8-69.5] vs. mYC score = 5, mean 36.7 months [95% CI: 12.7-60.7], vs. mYC score = 6, mean 10.7 months [95% CI: 3.9-17.4]). CONCLUSIONS: Modified Yonsei criteria score can predict long-term survival in resected left-sided pancreatic cancer. And patients within YC with a mYC score = 3 could have a favorable survival outcome.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165362
Full Text
https://www.sciencedirect.com/science/article/pii/S1424390318306641
DOI
10.1016/j.pan.2018.09.001
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
강창무(Kang, Chang Moo) ORCID logo https://orcid.org/0000-0002-5382-4658
노승윤(Rho, Seoung Yoon) ORCID logo https://orcid.org/0000-0002-1265-826X
윤미진(Yun, Mi Jin) ORCID logo https://orcid.org/0000-0002-1712-163X
이우정(Lee, Woo Jung) ORCID logo https://orcid.org/0000-0001-9273-261X
황호경(Hwang, Ho Kyoung) ORCID logo https://orcid.org/0000-0003-4064-7776
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