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Circulating Eosinophil and Neutrophil Counts Correlate with Disease Severity in Bullous Pemphigoid

Authors
 Seh Hyun Park  ;  Si-Hyung Lee  ;  Jong Hoon Kim  ;  Soo-Chan Kim 
Citation
 ANNALS OF DERMATOLOGY, Vol.30(5) : 544-549, 2018 
Journal Title
 ANNALS OF DERMATOLOGY 
ISSN
 1013-9087 
Issue Date
2018
Keywords
Bullous pemphigoid ; Eosinophil ; Leukocyte ; Neutrophil
Abstract
Background: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by tissue- bound and circulating autoantibodies directed against BP180 and/or BP230 antigens. Various inflammatory cells are involved in the development of blister in BP. Objective: The aim of this study was to evaluate the correlation between peripheral leukocyte counts and BP severity. Methods: We retrospectively included 60 patients with BP, who had not been treated with systemic steroid at the time of blood sampling. The patients were classified into two groups, those with admission history (admission group) and those without admission history (non-admission group). Disease severity was evaluated using three parameters: admission history, initial steroid dosage, and modified version of a pemphigus scoring system. We evaluated the correlation between peripheral leukocyte counts and disease severity measured by the three parameters. Results: The admission group showed a significant increase in disease severity measured by initial steroid dosage and severity score compared with the non-admission group. Additionally, the admission group had increased total leukocyte, eosinophil, and neutrophil counts. In the correlation study, the peripheral eosinophil and neutrophil counts showed positive correlation with BP severity evaluated by both initial steroid dosage and the pemphigus scoring system. Conclusion: Peripheral eosinophil and neutrophil counts can be used as a marker in predicting disease severity in patients with BP. (Ann Dermatol 30(5) 544∼549, 2018)
Files in This Item:
T201803850.pdf Download
DOI
10.5021/ad.2018.30.5.544
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Chan(김수찬) ORCID logo https://orcid.org/0000-0002-2327-4755
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165329
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