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Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy.

Authors
 Ji Hyun Chang  ;  Kyung Hwan  ;  Seung Do Ahn  ;  Hae Jin Park  ;  Eui Kyu Chie  ;  Jin Ho Kim  ;  Su Ssan Kim  ;  Yong Bae Kim  ;  Won Park  ;  Yeon-Joo Kim  ;  Hyun Soo Shin  ;  Jin Hee Kim  ;  Sun Young Lee  ;  Kyubo Kim  ;  Kyung Ran Park  ;  Bae Kwon Jeong  ;  Ja Young Kim  ;  Suzy Kim 
Citation
 BREAST CANCER RESEARCH AND TREATMENT, Vol.169(3) : 507-512, 2018 
Journal Title
 BREAST CANCER RESEARCH AND TREATMENT 
ISSN
 0167-6806 
Issue Date
2018
Keywords
1–3 positive nodes ; Breast cancer ; Chest wall irradiation ; Chest wall recurrence risk factor ; Post-mastectomy radiation therapy
Abstract
PURPOSE: In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT). METHODS: The data from the patients participating in two South Korean multi-institutional studies (KROG 14-22; N = 1842 and KROG 14-23; N = 1382) were analyzed. In total, 3224 pT1-2N0-1 breast cancer patients who underwent mastectomy without PMRT were analyzed. RESULTS: The median follow-up time was 72.2 months (range 0.8-125.2 months). The overall CWRs during the follow-up period were 1.68% in N0 patients and 2.82% in N1 patients. There was no statistically significant difference in 5-year and 10-year CWR-free survival (CWRFS) between the N0 and N1 patients. Of the 70 patients with CWR, 33 (1% of all the patients) had isolated CWR, and the 10-year overall survival rate in this group was 96.9%. After the propensity score matching of the N0 and N1 groups, there was still no difference in CWRFS by nodal status. CONCLUSIONS: The incidence of CWR in pT1-2N0-1 breast cancer patients is very low, especially with isolated recurrence. Also, the obtained data showed that the nodal status had no impact on CWRFS.
Full Text
https://link.springer.com/article/10.1007%2Fs10549-018-4707-0
DOI
10.1007/s10549-018-4707-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165324
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