Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy.
Authors
Ji Hyun Chang ; Kyung Hwan ; Seung Do Ahn ; Hae Jin Park ; Eui Kyu Chie ; Jin Ho Kim ; Su Ssan Kim ; Yong Bae Kim ; Won Park ; Yeon-Joo Kim ; Hyun Soo Shin ; Jin Hee Kim ; Sun Young Lee ; Kyubo Kim ; Kyung Ran Park ; Bae Kwon Jeong ; Ja Young Kim ; Suzy Kim
Citation
BREAST CANCER RESEARCH AND TREATMENT, Vol.169(3) : 507-512, 2018
1–3 positive nodes ; Breast cancer ; Chest wall irradiation ; Chest wall recurrence risk factor ; Post-mastectomy radiation therapy
Abstract
PURPOSE:
In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT).
METHODS:
The data from the patients participating in two South Korean multi-institutional studies (KROG 14-22; N = 1842 and KROG 14-23; N = 1382) were analyzed. In total, 3224 pT1-2N0-1 breast cancer patients who underwent mastectomy without PMRT were analyzed.
RESULTS:
The median follow-up time was 72.2 months (range 0.8-125.2 months). The overall CWRs during the follow-up period were 1.68% in N0 patients and 2.82% in N1 patients. There was no statistically significant difference in 5-year and 10-year CWR-free survival (CWRFS) between the N0 and N1 patients. Of the 70 patients with CWR, 33 (1% of all the patients) had isolated CWR, and the 10-year overall survival rate in this group was 96.9%. After the propensity score matching of the N0 and N1 groups, there was still no difference in CWRFS by nodal status.
CONCLUSIONS:
The incidence of CWR in pT1-2N0-1 breast cancer patients is very low, especially with isolated recurrence. Also, the obtained data showed that the nodal status had no impact on CWRFS.