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Axin2 overexpression promotes the early epithelial disintegration and fusion of facial prominences during avian lip development.

Authors
 Hye-Jin Tak  ;  Zhengguo Piao  ;  Hak-Jin Kim  ;  Sang-Hwy Lee 
Citation
 DEVELOPMENT GENES AND EVOLUTION, Vol.228(5) : 197-211, 2018 
Journal Title
 DEVELOPMENT GENES AND EVOLUTION 
ISSN
 0949-944X 
Issue Date
2018
Keywords
Axin2 ; Development ; Epithelial-mesenchymal transition ; Lip ; Wnt
Abstract
The epithelial disintegration and the mesenchymal bridging are critical steps in the fusion of facial prominences during the upper lip development. These processes of epithelial-mesenchymal transition and programmed cell death are mainly influenced by Wnt signals. Axis inhibition protein2 (Axin2), a major component of the Wnt pathway, has been reported to be involved in lip development and cleft pathogenesis. We wanted to study the involvement of Axin2 in the lip development, especially during the epithelial disintegration of facial prominences. Our results show that Axin2 was expressed mainly in the epithelium of facial prominences and decreased when the prominences were about to contact each other between Hamburger-Hamilton stages 27 and 28 of chicken embryos. The epithelial integrity was destructed or kept intact by the local gain or loss of Axin2 expression, resulting in morphological changes in the facial processes and their skeletal derivatives including the maxilla, nasal, premaxilla bone, and their junctions without cleft formation. These changes were related to expression changes in nuclear β-catenin, pGSK3β, Slug, Smad3, E-cadherin, and p63. All these data indicate that Axin2 participates in the regulation of epithelial integrity and fusion by promoting epithelial disassociation, basement membrane breakdown, and seam loss during the fusion of facial prominences in lip development.
Full Text
https://link.springer.com/article/10.1007%2Fs00427-018-0617-8
DOI
10.1007/s00427-018-0617-8
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hak Jin(김학진) ORCID logo https://orcid.org/0000-0001-6063-3406
Lee, Sang Hwy(이상휘) ORCID logo https://orcid.org/0000-0002-9438-2489
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165302
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