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MET in gastric cancer with liver metastasis: The relationship between MET amplification and Met overexpression in primary stomach tumors and liver metastasis.

 Han S. Kim  ;  Hong J. Chon  ;  Hyunki Kim  ;  Su‐Jin Shin  ;  Volker Wacheck  ;  Aaron M. Gruver  ;  Jong S. Kim  ;  Sun Y. Rha  ;  Hyun C. Chung 
 Journal of Surgical Oncology, Vol.117(8) : 1679-1686, 2018 
Journal Title
 Journal of Surgical Oncology 
Issue Date
Female ; Gene Amplification ; Gene Expression ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Liver Neoplasms/metabolism* ; Liver Neoplasms/mortality* ; Liver Neoplasms/secondary ; Male ; Middle Aged ; Prognosis ; Proto-Oncogene Proteins c-met/genetics ; Proto-Oncogene Proteins c-met/metabolism* ; Republic of Korea/epidemiology ; Stomach Neoplasms/metabolism* ; Stomach Neoplasms/mortality* ; Stomach Neoplasms/pathology
Met ; amplification ; gastric cancer ; liver metastasis ; overexpression
BACKGROUND AND OBJECTIVES: Although MET amplification/overexpression was observed in a subset of gastric cancer (GC) patients, the relationship between MET amplification/overexpression in primary GC and liver metastasis was unclear. METHODS: GC samples and matched liver metastases (N = 47) were analyzed by fluorescence/silver in-situ hybridization (FISH/SISH) and by immunohistochemistry for MET amplification and MET expression, respectively. MET-copy number (CN) and Met expression data from The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA-STAD, N = 356) were also analyzed. RESULTS: Significant overlap existed between MET amplification and Met expression in both primary stomach tumors (P = 0.013) and liver metastasis (P = 0.001). In TCGA-STAD, MET-CN (≥4 copies) and MET expression were also positively correlated (r = 0.761; P = 0.017). Comparative analysis revealed a strong association between MET expression and MET amplification (85% concurrence) in primary stomach tumors and matched liver metastasis. MET status in synchronous liver metastasis (N = 36) was correlated with primary stomach tumors. However, a significant correlation between primary tumors and liver metastases was not observed in patients with metachronous liver metastasis. Survival analyses revealed that both MET amplification and MET overexpression were prognostic of poor outcomes. CONCLUSIONS: MET amplification and Met overexpression were positively correlated in GC. MET status should be re-evaluated in GC patients with liver metastasis, especially for metachronous metastasis.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김한상(Kim, Han Sang) ORCID logo https://orcid.org/0000-0002-6504-9927
김현기(Kim, Hyunki) ORCID logo https://orcid.org/0000-0003-2292-5584
라선영(Rha, Sun Young) ORCID logo https://orcid.org/0000-0002-2512-4531
정현철(Chung, Hyun Cheol) ORCID logo https://orcid.org/0000-0002-0920-9471
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