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Usefulness of dynamic risk stratification in pediatric patients with differentiated thyroid carcinoma.

Authors
 Kwangsoon Kim  ;  Won Woong Kim  ;  Jung Bum Choi  ;  Min Jhi Kim  ;  Cho Rok Lee  ;  Jandee Lee  ;  Sang-Wook Kang  ;  Kee-Hyun Nam  ;  Woong Youn Chung  ;  Jong Ju Jeong 
Citation
 ANNALS OF SURGICAL TREATMENT AND RESEARCH, Vol.95(4) : 222-229, 2018 
Journal Title
ANNALS OF SURGICAL TREATMENT AND RESEARCH
ISSN
 2288-6575 
Issue Date
2018
Keywords
Pediatrics ; Thyroid cancer
Abstract
Purpose:

Recently, the American Thyroid Association (ATA) dynamic risk stratification (DRS) has been verified to be more valuable than the static anatomical staging system for predicting prognosis in patients with differentiated thyroid carcinoma (DTC). The purpose of this retrospective study was to compare the clinical usefulness of DRS, which is based on the response to initial treatment, with that of ATA initial risk stratification in pediatric patients.

Methods:

A total of 144 pediatric patients underwent thyroid operation from August 1982 to December 2013 at Yonsei University Hospital (Seoul, Korea). Among them, 128 patients with complete clinical data were enrolled in this study. Clinicopathologic features and surgical outcomes were retrospectively analyzed by medical chart review. The mean follow-up duration was 11.5 years.

Results:

The mean tumor size was 2.1 cm; 80.4% of patients were diagnosed with conventional papillary thyroid carcinoma, and 7.0% of patients were diagnosed with follicular thyroid carcinoma. Low-risk patients had the highest probability of an excellent response to initial treatment (66.6%). High-risk patients had the highest probability of a structural incomplete response (100%) and the lowest probability of an excellent response (11.1%). The ATA risk stratification and the DRS system were independent risk factors for disease-free survival (DFS) (P = 0.041 and P < 0.001, respectively).

Conclusion:

The DRS system, which is based on the response to initial treatment, can offer more useful prognostic information compared with ATA risk stratification in pediatric patients with DTC.
Files in This Item:
T201803776.pdf Download
DOI
10.4174/astr.2018.95.4.222
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Wook(강상욱) ORCID logo https://orcid.org/0000-0001-5355-833X
Kim, Kwang Soon(김광순)
Kim, Min Jhi(김민지)
Kim, Won Woong(김원웅)
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Lee, Jan Dee(이잔디) ORCID logo https://orcid.org/0000-0003-4090-0049
Lee, Cho Rok(이초록) ORCID logo https://orcid.org/0000-0001-7848-3709
Chung, Woong Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
Choi, Jung Bum(최정범)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165289
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