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Usefulness of dynamic risk stratification in pediatric patients with differentiated thyroid carcinoma.

 Kwangsoon Kim  ;  Won Woong Kim  ;  Jung Bum Choi  ;  Min Jhi Kim  ;  Cho Rok Lee  ;  Jandee Lee  ;  Sang-Wook Kang  ;  Kee-Hyun Nam  ;  Woong Youn Chung  ;  Jong Ju Jeong 
 Annals of Surgical Treatment and Research, Vol.95(4) : 222-229, 2018 
Journal Title
 Annals of Surgical Treatment and Research 
Issue Date
Pediatrics ; Thyroid cancer
Purpose: Recently, the American Thyroid Association (ATA) dynamic risk stratification (DRS) has been verified to be more valuable than the static anatomical staging system for predicting prognosis in patients with differentiated thyroid carcinoma (DTC). The purpose of this retrospective study was to compare the clinical usefulness of DRS, which is based on the response to initial treatment, with that of ATA initial risk stratification in pediatric patients. Methods: A total of 144 pediatric patients underwent thyroid operation from August 1982 to December 2013 at Yonsei University Hospital (Seoul, Korea). Among them, 128 patients with complete clinical data were enrolled in this study. Clinicopathologic features and surgical outcomes were retrospectively analyzed by medical chart review. The mean follow-up duration was 11.5 years. Results: The mean tumor size was 2.1 cm; 80.4% of patients were diagnosed with conventional papillary thyroid carcinoma, and 7.0% of patients were diagnosed with follicular thyroid carcinoma. Low-risk patients had the highest probability of an excellent response to initial treatment (66.6%). High-risk patients had the highest probability of a structural incomplete response (100%) and the lowest probability of an excellent response (11.1%). The ATA risk stratification and the DRS system were independent risk factors for disease-free survival (DFS) (P = 0.041 and P < 0.001, respectively). Conclusion: The DRS system, which is based on the response to initial treatment, can offer more useful prognostic information compared with ATA risk stratification in pediatric patients with DTC.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
강상욱(Kang, Sang Wook) ORCID logo https://orcid.org/0000-0001-5355-833X
김광순(Kim, Kwang Soon)
김민지(Kim, Min Jhi)
김원웅(Kim, Won Woong)
남기현(Nam, Kee Hyun) ORCID logo https://orcid.org/0000-0002-6852-1190
이잔디(Lee, Jan Dee) ORCID logo https://orcid.org/0000-0003-4090-0049
이초록(Lee, Cho Rok) ORCID logo https://orcid.org/0000-0001-7848-3709
정웅윤(Chung, Woung Youn)
정종주(Jeong, Jong Ju) ORCID logo https://orcid.org/0000-0002-4155-6035
최정범(Choi, Jung Bum)
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