In this paper, we designed a multimodal bio-signal measurement system to observe changes in the brain nervous system and vascular system during sleep. Changes in the nervous system and the cerebral blood flow system in the brain during sleep induce a unique correlation between the changes in the nervous system and the blood flow system. Therefore, it is necessary to simultaneously observe changes in the brain nervous system and changes in the blood flow system to observe the sleep state. To measure the change of the nervous system, EEG, EOG and EMG signal used for the sleep stage analysis were designed. We designed a system for measuring cerebral blood flow changes using functional near-infrared spectroscopy. Among the various imaging methods to measure blood flow and metabolism, it is easy to measure simultaneously with EEG signal and it can be easily designed for miniaturization of equipment. The sleep stage was analyzed by the measured data, and the change of the cerebral blood flow was confirmed by the change of the sleep stage.