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Up-regulation of HOXB cluster genes are epigenetically regulated in tamoxifen-resistant MCF7 breast cancer cells.

DC Field Value Language
dc.contributor.author김명희-
dc.contributor.author이지연-
dc.contributor.author오지훈-
dc.date.accessioned2018-11-16T16:41:52Z-
dc.date.available2018-11-16T16:41:52Z-
dc.date.issued2018-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165234-
dc.description.abstractTamoxifen (TAM) is commonly used to treat estrogen receptor (ER)-positive breast cancer. Despite the remarkable benefits, resistance to TAM presents a serious therapeutic challenge. Since several HOX transcription factors have been proposed as strong candidates in the development of resistance to TAM therapy in breast cancer, we generated an in vitro model of acquired TAM resistance using ER-positive MCF7 breast cancer cells (MCF7-TAMR), and analyzed the expression pattern and epigenetic states of HOX genes. HOXB cluster genes were uniquely up-regulated in MCF7-TAMR cells. Survival analysis of in slico data showed the correlation of high expression of HOXB genes with poor response to TAM in ER-positive breast cancer patients treated with TAM. Gain- and loss-of-function experiments showed that the overexpression of multi HOXB genes in MCF7 renders cancer cells more resistant to TAM, whereas the knockdown restores TAM sensitivity. Furthermore, activation of HOXB genes in MCF7-TAMR was associated with histone modifications, particularly the gain of H3K9ac. These findings imply that the activation of HOXB genes mediate the development of TAM resistance, and represent a target for development of new strategies to prevent or reverse TAM resistance.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society for Biochemistry and Molecular Biology-
dc.relation.isPartOfBMB REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleUp-regulation of HOXB cluster genes are epigenetically regulated in tamoxifen-resistant MCF7 breast cancer cells.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.googleauthorSeoyeon Yang-
dc.contributor.googleauthorJi-Yeon Lee-
dc.contributor.googleauthorHo Hur-
dc.contributor.googleauthorJi Hoon Oh-
dc.contributor.googleauthorMyoung Hee Kim-
dc.identifier.doi10.5483/BMBRep.2018.51.9.020-
dc.contributor.localIdA00432-
dc.contributor.localIdA03194-
dc.relation.journalcodeJ00348-
dc.identifier.eissn1976-670X-
dc.identifier.pmid29804556-
dc.subject.keywordBreast cancer-
dc.subject.keywordHistone modification-
dc.subject.keywordHOX genes-
dc.subject.keywordTamoxifen resistance-
dc.contributor.alternativeNameKim, Myoung Hee-
dc.contributor.alternativeNameLee, Ji Yeon-
dc.contributor.affiliatedAuthor김명희-
dc.contributor.affiliatedAuthor이지연-
dc.citation.volume51-
dc.citation.number9-
dc.citation.startPage450-
dc.citation.endPage455-
dc.identifier.bibliographicCitationBMB REPORTS, Vol.51(9) : 450-455, 2018-
dc.identifier.rimsid58651-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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